ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate | 77670-31-6

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate
• 英文别名: methyl-(3-oxo-1,3-diphenyl-propyl)-malonic acid diethyl ester；Methyl-(3-oxo-1,3-diphenyl-propyl)-malonsaeure-diaethylester；diethyl 2-methyl-2-(3-oxo-1,3-diphenylpropyl)propanedioate
• CAS: 77670-31-6
• 化学式: C₂₃H₂₆O₅
• 分子量: 382.456
• InChiKey: CVXQGVFBRFCBFA-UHFFFAOYSA-N

物化性质

• 熔点：
  90-93 °C
• 沸点：
  502.3±50.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  28.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  69.67
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  乙醚 、 ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate 、 sodium ethanolate 生成 甲基丙二酸二乙酯 、 反式-查耳酮
  参考文献：
  名称：

  The Course of Addition of the Sodium Enolates of Malonic and Methylmalonic Esters to Benzalacetophenone and to Crotonic Ester

  摘要：

  DOI：

  10.1021/ja01331a053
• 作为产物：
  描述：

  甲基丙二酸二乙酯 、 反式-查耳酮 在 sodium hydroxide 、 (-)-N-十二基-N-甲基麻黄碱溴化物 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以60%的产率得到ethyl γ-benzoyl-α-ethoxycarbonyl-α-methyl-β-phenylbutyrate
  参考文献：
  名称：

  源自金鸡纳和麻黄生物碱的手性相转移催化剂在迈克尔反应中的不对称诱导

  摘要：

  在生物碱的两相体系中，除了分别添加硫醇和硝基烷烃的αβ-不饱和酮外，在两相系统中使用生物碱盐的光学收率分别高达36％和26％，从而实现了迈克尔反应中的不对称诱导。on官能团的羟基β的存在对于实现基本的不对称合成是必不可少的。

  DOI：

  10.1039/p19810000547

文献信息

• L’epinephrine réduit les effets secondaires sédatifs du sufentanil épidural administré pour l’analgésie pendant le travail
  作者：Kevin P. Armstrong、Brent Kennedy、James T. Watson、Patricia K. Morley-Forster、Irvan Yee、Ronald Butler

  DOI：10.1007/bf03020422

  日期：2002.1

  Purpose: The use of opioids in labour analgesia has primarily been as an adjuvant to local anesthetics. For early labour, satisfactory analgesia with epidural sufentanil alone is possible. This study evaluates the impact of epinephrine on sedative side effects and analgesia related to the latter technique.Methods: After Institutional Review Board approval and informed consent this prospective, randomized, double-blind study evaluated 43 nulliparous subjects requesting epidural analgesia. The study site, a tertiary care obstetric unit, accommodates 3500-4500 deliveries annually. Group selection was randomized and blinded by selection of a sealed envelope containing a number which corresponded to a premixed labelled syringe of saline or epinephrine (100 mug(.)mL(-1)). An epidural catheter was placed in a standardized fashion. All subjects received 40 mug of sufentanil and 0.5 mL from the premixed syringe, diluted to 10 mL with NaCl. A blinded observer collected data on maternal sedation, lightheadedness, hemodynamics, oxygenation, and fetal heart rate over a one-hour period following sufentanil injection.Results: The addition of epinephrine significantly (P <0.05) reduced the incidence of sedation and lightheadedness after epidural sufentanil at all data collection points, except two. Analgesic duration was also significantly prolonged by this addition (120 +/- 56 vs 84 +/- 32 min). Maternal satisfaction was high regardless of solution.Conclusion: Forty micrograms of epidural sufentanil produces satisfactory analgesia in early labour. The addition of epinephrine improves the side effect profile of this technique while prolonging the duration of analgesia. Epidural sufentanil requires attention to maternal monitoring of oxygenation as maternal desaturation occurred in both groups.