trehalose | 74496-97-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trehalose
• 英文别名: α-D-Glucopyranosyl β-L-glucopyranoside；α,β-trehalose；α,α-trehalose；alpha, beta-Trehalose；(2S,3R,4R,5S,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol
• CAS: 74496-97-2
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: HDTRYLNUVZCQOY-WFNFTJJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 trehalose 在 吡啶 、 4-二甲氨基吡啶 作用下， 反应 2.0h， 生成 2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl 2,3,4,6-tetra-O-acetyl-β-L-glucopyranoside
  参考文献：
  名称：

  Roennow, Tor E. C. L.; Meldel, Morten; Bock, Klaus, Journal of Carbohydrate Chemistry, 1995, vol. 14, # 2, p. 197 - 212

  摘要：

  DOI：
• 作为产物：
  描述：

  (2S,3R,4R,5S,6R)-2-Hydroxymethyl-6-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3,4,5-triol 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 24.0h， 生成 trehalose
  参考文献：
  名称：

  Roennow, Tor E. C. L.; Meldel, Morten; Bock, Klaus, Journal of Carbohydrate Chemistry, 1995, vol. 14, # 2, p. 197 - 212

  摘要：

  DOI：

文献信息

• FLUORESCENT ANTICANCER PLATINUM DRUGS
  申请人：INVICTUS ONCOLOGY PVT. LTD.

  公开号：US20180312534A1

  公开（公告）日：2018-11-01

  The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

  本公开涉及纳米技术和癌症治疗领域。具体而言，本公开涉及荧光铂基化合物。该公开进一步涉及合成所述荧光铂基化合物、纳米颗粒和包含所述荧光铂基化合物/纳米颗粒的组合物。该公开还涉及通过上述铂基化合物与相应的游离配体、纳米颗粒和组合物之间的荧光变化来管理癌症的方法。
• CONTINUOUS PROCESSES FOR THE HIGHLY SELECTIVE CONVERSION OF ALDOHEXOSE-YIELDING CARBOHYDRATE TO ETHYLENE GLYCOL
  申请人：Iowa Corn Promotion Board

  公开号：US20170349513A1

  公开（公告）日：2017-12-07

  Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol.

  揭示了制备乙二醇形成醛己糖产生的连续过程，这些过程增强了对乙二醇的选择性。
• PROCESS TO PRODUCE 5-HYDROXYMETHYLFURFURAL (HMF) FROM CARBOHYDRATES USING A SOLVENT SYSTEM CONTAINING WATER AND A POLAR APROTIC SOLVENT
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20200039947A1

  公开（公告）日：2020-02-06

  A method to produce 5-hydroxymethylfurfural (HMF) from C6 carbohydrates. The method includes the steps of reacting a reactant comprising at least one C6 carbohydrate, in a reaction mixture comprising at least about 5% (v/v) water, a polar, aprotic solvent, and an acid, for a time, at a temperature, and at a hydrogen ion concentration wherein at least a portion of the C6 carbohydrate present in the reactant is converted to 5-hydroxymethyl furfural (“HMF”).

  一种从C6碳水化合物生产5-羟甲基糠醛（HMF）的方法。该方法包括以下步骤：在反应混合物中，将至少含有一种C6碳水化合物的反应物与至少约5%（体积/体积）水、极性、无水性溶剂和酸反应，反应时间、温度和氢离子浓度使反应物中至少部分的C6碳水化合物转化为5-羟甲基糠醛（“HMF”）。
• METHOD TO CONVERT MONOSACCHARIDES TO 5-(HYDROXYMETHYL) FURFURAL (HMF) USING BIOMASS-DERIVED SOLVENTS
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20140107355A1

  公开（公告）日：2014-04-17

  Described is a process to produce hydroxymethyl furfural (HMF) from biomass-derived sugars. The process includes the steps of reacting a C5 and/or C6 sugar-containing reactant derived from biomass in a monophasic or biphasic reaction solution comprising water and a co-solvent. The co-solvent can be beta-, gamma-, and/or delta-lactones derived from biomass, tetrahydrofuran (THF) derived from biomass, and/or methyltetrahydrofuran (MTHF) derived from biomass. The reaction takes place in the presence of an acid catalyst and a dehydration catalyst for a time and under conditions such that at least a portion of glucose or fructose present in the reactant is converted to HMF.

  描述了一种从生物质衍生的糖产生羟甲基糠醛（HMF）的过程。该过程包括以下步骤：在包含水和共溶剂的单相或双相反应溶液中，将从生物质中衍生的C5和/或C6糖含量的反应物与酸催化剂和脱水催化剂一起反应，共溶剂可以是从生物质中衍生的β-、γ- 和/或δ-内酯、从生物质中衍生的四氢呋喃（THF）和/或从生物质中衍生的甲基四氢呋喃（MTHF）。在一定时间和条件下，在酸催化剂和脱水催化剂的存在下，使反应物中存在的葡萄糖或果糖的至少一部分转化为HMF。
• METHOD TO PRODUCE WATER-SOLUBLE SUGARS FROM BIOMASS USING SOLVENTS CONTAINING LACTONES
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20140194619A1

  公开（公告）日：2014-07-10

  A process to produce an aqueous solution of carbohydrates that contains C6-sugar-containing oligomers, C6 sugar monomers, C5-sugar-containing oligomers, C5 sugar monomers, or any combination thereof is presented. The process includes the steps of reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. A solute is added to the product mixture to cause partitioning of the product mixture into an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone.

  提供一种生产含有C6糖类寡聚体、C6糖单体、C5糖类寡聚体、C5糖单体或其任意组合的碳水化合物水溶液的方法。该方法包括将生物质或生物质衍生物反应于包括内酯和水以及酸性催化剂的溶剂体系中。反应产生一个产物混合物，其中包含水溶性的C6糖类寡聚体、C6糖单体、C5糖类寡聚体、C5糖单体或其任意组合。向产物混合物中添加一种溶质，使产物混合物分配为含有碳水化合物的水层和含有内酯的基本不混溶的有机层。