(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-iodophenoxy)oxane-3,4,5-triol | 145874-99-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-iodophenoxy)oxane-3,4,5-triol
• CAS: 145874-99-3
• 化学式: C₁₂H₁₅IO₆
• 分子量: 382.152
• InChiKey: UMDHSEVUHJVYNA-YBXAARCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-iodophenoxy)oxane-3,4,5-triol 在 tetrafluoroboric acid 、 四丁基溴化铵 、 二正丁基氧化锡 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成
  参考文献：
  名称：

  Functionalized Glycomers as Growth Inhibitors and Inducers of Apoptosis in Human Glioblastoma Cells

  摘要：

  The effects of functionalized aryl beta-D-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by these molecules in human glioblastoma cells. Inhibition of DNA synthesis precedes induction of apoptosis and growth inhibition. The substituents at C-1, C-2, C-3,C-4, and C-6 on the pyranosidic scaffold are important to modulate the action and the efficacy of these molecules. Human fibroblasts and brain-derived endothelial cells were less sensitive to glycomers than tumor cells. Thus, functionalized aryl beta-D-glycopyranosides represent a new class of molecules potentially able to control the progression of brain tumors.

  DOI：

  10.1021/jm0205853
• 作为产物：
  描述：

  O-(4-iodophenyl)-(2,3,4,6-O-tetraacetyl)-β-D-galactopyranose 在 甲醇 、 sodium methylate 作用下， 生成 (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(4-iodophenoxy)oxane-3,4,5-triol
  参考文献：
  名称：

  Functionalized Glycomers as Growth Inhibitors and Inducers of Apoptosis in Human Glioblastoma Cells

  摘要：

  The effects of functionalized aryl beta-D-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by these molecules in human glioblastoma cells. Inhibition of DNA synthesis precedes induction of apoptosis and growth inhibition. The substituents at C-1, C-2, C-3,C-4, and C-6 on the pyranosidic scaffold are important to modulate the action and the efficacy of these molecules. Human fibroblasts and brain-derived endothelial cells were less sensitive to glycomers than tumor cells. Thus, functionalized aryl beta-D-glycopyranosides represent a new class of molecules potentially able to control the progression of brain tumors.

  DOI：

  10.1021/jm0205853

文献信息

• Chemiluminescent method and compositions
  申请人：LUMIGEN, INC.

  公开号：EP0516948A1

  公开（公告）日：1992-12-09

  A chemiluminescent method using a protected enhancer compound which is triggered by a hydrolytic enzyme and then enhances a chemiluminescent reaction is described. The reaction involves an amino substituted acylhydrazide which is activated to produce light by a peroxide compound and a peroxidase in the presence of the activated enhancer compound. The result is enhanced generation of light from the reaction. The hydrolytic enzyme is present alone or as a label in an immunoassay, DNA probe assay or other assay wherein the hydrolytic enzyme is bound to a reporter molecule.

  描述了一种使用受保护的增强剂化合物的化学发光方法，该增强剂化合物由水解酶引发，然后增强化学发光反应。该反应涉及一种氨基取代的酰肼，在活化的增强剂化合物存在下，酰肼被过氧化物化合物和过氧化物酶活化产生光。反应的结果是增强了光的产生。水解酶可单独存在，也可作为免疫测定、DNA 探针检测或其他检测中的标记，其中水解酶与报告分子结合。
• CHEMILUMINESCENT DETECTION OF HYDROLYTIC ENZYMES USING AN ACRIDAN
  申请人：LUMIGEN, INC.

  公开号：EP0778947B1

  公开（公告）日：2004-05-12
• Methods and reagents for analyte detection
  申请人：Liu Qun

  公开号：US20110097723A1

  公开（公告）日：2011-04-28

  The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using chemiluminescent and fluorescent molecule/enzyme coupled with analyte binding molecules to detect specific analyte molecules. Another aspect of the current invention is to use gold nanoparticle triggered chemiluminescent reaction to detect analyte.
• METHODS AND REAGENTS FOR ANALYTE DETECTION
  申请人：ORANGENE INC.

  公开号：US20150323541A1

  公开（公告）日：2015-11-12

  The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using chemiluminescent and fluorescent molecule/enzyme coupled with analyte binding molecules to detect specific analyte molecules. Another aspect of the current invention is to use gold nanoparticle triggered chemiluminescent reaction to detect analyte.
• Luminescence methods and reagents for analyte detection
  申请人：Wang Tianxin

  公开号：US20160033497A1

  公开（公告）日：2016-02-04

  The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using first analyte binding molecule labeled solid phase support encapsulated with chemiluminescent dye and chemiluminescent reaction generating molecule or enzyme coupled with second analyte binding molecules such as antibody HRP conjugate to detect specific analyte molecules. Another aspect of the current invention is that the analyte binding molecule labeled solid phase support encapsulated with chemiluminescent dye is magnetic.