4-O-acetyl-ascofuranone diethylacetal | 748798-50-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-O-acetyl-ascofuranone diethylacetal
• 英文别名: diEtAcAF；[2-chloro-4-(diethoxymethyl)-6-[(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxooxolan-2-yl]-3-methylocta-2,6-dienyl]-5-hydroxy-3-methylphenyl] acetate
• CAS: 748798-50-7
• 化学式: C₂₉H₄₁ClO₇
• 分子量: 537.093
• InChiKey: BVNZBDAYIXLSAH-IKTNUDMYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method for preparing novel transcription factors and use
  申请人：Kitahara Takeshi

  公开号：US20070054966A1

  公开（公告）日：2007-03-08

  The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.

  本发明的目的是开发新的化合物，用于治疗综合征X、癌症、黏液水肿、血管慢性炎症等疾病，并且预防/治疗由气球或支架扩张引起的动脉再狭窄，通过抑制自体细胞或组织的排斥反应促进再生医学，并提供制备这些化合物的方法。发现通过对ascochlorin及其类似物中2-位置的羟基进行酰化，并在碱性催化剂存在下将醇键合到醛基上，可以实现这一目标，从而获得新的缩醛衍生物。
• US7432306B2
  申请人：——

  公开号：US7432306B2

  公开（公告）日：2008-10-07