4-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]butanal | 212117-38-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]butanal
• CAS: 212117-38-9
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: LVVDOQIZCGLNLN-SSDOTTSWSA-N

物化性质

• 沸点：
  289.8±15.0 °C(Predicted)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]butanal 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 sodium cyanoborohydride 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 二氯甲烷 、 邻二甲苯 、 间二甲苯 、 xylene 为溶剂， 生成 (S)-2-{(R)-3-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoyloxy]-2-oxo-azepan-1-yl}-4-methyl-pentanoic acid (R)-1-carboxy-2-phenyl-ethyl ester
  参考文献：
  名称：

  Epsilon-lactam analogs of the anthelmintic cyclodepsipeptide PF1022A

  摘要：

  Conformationally restricted analogs of the anthelmintic cyclodepsipeptide PF1022A 1 were prepared by fusing a seven-membered lactam ring onto the macrocycle. Following the preparation of cyclodepsipeptide (CDP) 2 by classical chemical methods, CDPs 2 and 3 were synthesized using solid phase methodology involving cyclization-cleavage from an oxime resin. (C) 1998 Elsevier Science Ltd; All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01075-2
• 作为产物：
  描述：

  2,2-二甲氧基丙烷 在 palladium on activated charcoal 三氟化硼四氢呋喃络合物 、 氢气 、 4-甲基苯磺酸吡啶 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 、 乙酸乙酯 、 甲苯 为溶剂， 反应 1.5h， 生成 4-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]butanal
  参考文献：
  名称：

  Epsilon-lactam analogs of the anthelmintic cyclodepsipeptide PF1022A

  摘要：

  Conformationally restricted analogs of the anthelmintic cyclodepsipeptide PF1022A 1 were prepared by fusing a seven-membered lactam ring onto the macrocycle. Following the preparation of cyclodepsipeptide (CDP) 2 by classical chemical methods, CDPs 2 and 3 were synthesized using solid phase methodology involving cyclization-cleavage from an oxime resin. (C) 1998 Elsevier Science Ltd; All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01075-2

文献信息

• Restricted Conformation Analogues of an Anthelmintic Cyclodepsipeptide
  作者：Fred E. Dutton、Byung H. Lee、Sandra S. Johnson、Eileen M. Coscarelli、Pil H. Lee

  DOI：10.1021/jm020482k

  日期：2003.5.1

  Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, each containing a small ring fused to the macrocycle to restrict the number of conformations the larger ring can adopt. It was anticipated that such conformational changes could lead to enhanced biological activity and selectivity. The analogues form two series of three members each. In one series, a carbon-based molecular bridge joins the methyl of a leucine residue with the methyl of its closest lactic acid residue to form five-, six-, and seven-membered lactam rings. In the second series, a leucine residue is replaced with five-, six-, and seven-membered nitrogen heterocycles. Decreasing the size of the small ring in the lactam. series increasingly distorts the macrocycle and consistently decreases activity relative to PF1022A. In the leucine series, a similar trend is observed. Molecular modeling of PF1022A along with the analogues described herein suggests that the ability to exist in a highly symmetrical conformational state is a necessary condition for biological activity.