4-[1-(1,3-苯并二氧戊环-5-基)-1,3,3a,4,6,6a-六氢呋喃并[4,3-c]呋喃-4-基]-2-甲氧基苯酚 | 54983-95-8

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 中文名称: 4-[1-(1,3-苯并二氧戊环-5-基)-1,3,3a,4,6,6a-六氢呋喃并[4,3-c]呋喃-4-基]-2-甲氧基苯酚
• 英文名称: 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]-octane
• 英文别名: Xanthoxylol；4-[3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenol
• CAS: 54983-95-8；111407-29-5
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: VBIRCRCPHNUJAS-UHFFFAOYSA-N

物化性质

• LogP：
  2.827 (est)
• 物理描述：
  Solid
• 熔点：
  140-142°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Process for production of dihomo-gamma-linolenic acid and lipid containing same
  申请人：——

  公开号：US20010021522A1

  公开（公告）日：2001-09-13

  A process for the production of dihomo-&ggr;-linolenic acid comprising the steps of culturing a microorganism having an ability to produce araquidonic acid and having a reduced or lost &Dgr;5 desaturase activity to produce dihomo-&ggr;-linolenic acid or a lipid containing dihomo-&ggr;-linolenic acid, and recovering the dihomo-&ggr;-linolenic acid.

  一种生产二十二碳六烯酸的方法，包括以下步骤：培养一种具有产生花生四烯酸能力且具有降低或失去Δ5脱饱和酶活性的微生物，以产生二十二碳六烯酸或含有二十二碳六烯酸的脂质，并回收二十二碳六烯酸。
• Medicament for the treatment of thrombus, inflammation and high blood pressure
  申请人：SUNTORY LIMITED

  公开号：EP0387000A2

  公开（公告）日：1990-09-12

  A composition for inhibiting Δ⁵-desaturase comprising an effective ingredient selected from the group consisting of lignan compounds, curcumin and piperonyl butoxide. As the lignan compounds sesamin, sesaminol, episesamin, episesaminol, sesamolin, 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-­hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo­[3.3.0]octane, and 2-(3,4-methylenedioxyphenyl)-6-­(3-methoxy-4-hydroxyphenoxy)-3,7-dioxabicyclo[3.3.0]­octane are used. Moreover the effective ingredient may be a sesame oil extract or sesame seed extract.

  一种抑制Δ⁵-去饱和酶的组合物，其有效成分选自由木质素化合物、姜黄素和胡椒基丁醚组成的组。木质素化合物包括芝麻素、芝麻素醇、表芝麻素、表芝麻素醇、芝麻酚、2-(3,4-亚甲基二氧苯基)-6-(3-甲氧基-4-羟基苯基)-3,7-二氧杂环[3.3.0]辛烷、2,6-双-(3-甲氧基-4-羟基苯基)-3,7-二氧杂环[3.3.0]辛烷和 2-(3,4-亚甲基二氧苯基)-6-(3-甲氧基-4-羟基苯氧基)-3,7-二氧杂环[3.3.0]辛烷。此外，有效成分可以是芝麻油提取物或芝麻籽提取物。
• Liver function improver
  申请人：SUNTORY LIMITED

  公开号：EP0409654A2

  公开（公告）日：1991-01-23

  A liver function improver, food, or drink comprising, as an effective ingredient, a dioxabicyclo­[3.3.0]octane derivative, such as sesamin, sesaminol episesamin, episesaminol, sesamolin, 2-(3,4-­methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-­3,7-dioxabicyclo[3.3.0]octane, 2,6-bis-(3-methoxy-4-­hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane or 2-(3,4-methylenedioxyphenyl)-6-(3-methoxy-4-hydroxyphen­oxy)-3,7-dioxabicyclo[3.3.0]octane.

  一种肝功能改善剂、食品或饮料，其有效成分包括二氧杂环[3.3.0]辛烷衍生物，如芝麻素、芝麻素酚表芝麻素、表芝麻素酚、芝麻素、2-(3,4-亚甲基二氧苯基)-6-(3-甲氧基-4-羟基苯基)-3,7-二氧杂环[3.3.3.0]辛烷、2,6-双(3-甲氧基-4-羟基苯基)-3,7-二氧杂环[3.3.0]辛烷或 2-(3,4-亚甲基二氧苯基)-6-(3-甲氧基-4-羟基苯氧基)-3,7-二氧杂环[3.3.0]辛烷。
• Use of dioxabicyclo [3.3.0]octane derivatives for the manufacture of a medicament for inhibiting the metabolism of cholesterol.
  申请人：SUNTORY LIMITED

  公开号：EP0488513A2

  公开（公告）日：1992-06-03

  A method of inhibiting the metabolism of cholesterol, comprising administering to a subject a pharmaceutical composition comprising a dioxabicyclo[3.3.0]octane derivative represented by the following general formula (I): wherein R¹, R², R³, R⁴, R⁵ and R⁶ independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R¹ and R² and/or R⁴ and R⁵ together form a methylene group or an ethylene group, and n, m and ℓ are 0 or 1.

  一种抑制胆固醇代谢的方法，包括向受试者施用一种药物组合物，该药物组合物包含由下式通式 (I) 所代表的二恶英双环[3.3.0]辛烷衍生物： 其中 R¹、R²、R³、R⁴、R⁵ 和 R⁶ 独立地代表氢原子或具有 1 至 3 个碳原子的烷基，或 R¹ 和 R² 和/或 R⁴ 和 R⁵ 共同形成亚甲基或亚乙基，且 n、m 和 ℓ 为 0 或 1。
• Composition containing dioxabicyclo[3.3.0]octane derivative
  申请人：SUNTORY LIMITED

  公开号：EP0519673A1

  公开（公告）日：1992-12-23

  A food, drink, pharmaceutical, cosmetic composition of food additive comprising a dioxabicyclo[3.3.0]octane derivative represented by the following general formula (I): wherein R¹, R², R³, R⁴, R⁵ and R⁶ independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, or R¹ and R² and/or R⁴ and R⁵ together form a methylene group or an ethylene group, and n, m and ℓ are 0 or 1; and antioxidant.

  一种食品、饮料、药品、化妆品的食品添加剂组合物，包含由下式通式 (I) 代表的二恶英双环[3.3.0]辛烷衍生物： 其中 R¹、R²、R³、R⁴、R⁵ 和 R⁶ 独立地代表氢原子或具有 1 至 3 个碳原子的烷基，或 R¹ 和 R² 和/或 R⁴ 和 R⁵ 共同形成亚甲基或亚乙基，且 n、m 和 ℓ 为 0 或 1；以及抗氧化剂。