4-[2-(3,4,5-三甲氧基苯基)乙烯基]喹啉 | 2859-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-[2-(3,4,5-三甲氧基苯基)乙烯基]喹啉
• 英文名称: 4-[(E)-2-(3,4,5-Trimethoxy-phenyl)-vinyl]-quinoline
• 英文别名: 4-(2-(3,4,5-Trimethoxyphenyl)vinyl)quinoline；4-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]quinoline
• CAS: 2859-98-5
• 化学式: C₂₀H₁₉NO₃
• 分子量: 321.376
• InChiKey: PAZAXHPAPRUCGE-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苄醇 在 正丁基锂 、 三溴化磷 作用下， 以 四氢呋喃 、 乙醚 、 甲苯 为溶剂， 生成 4-[2-(3,4,5-三甲氧基苯基)乙烯基]喹啉
  参考文献：
  名称：

  A new family of quinoline and quinoxaline analogues of combretastatins

  摘要：

  The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In this paper we show that the 6- or 7-quinolyl systems can in turn replace both cyclic moieties, keeping in the first case most of the potency as cytotoxic agent and in the second case as inhibitor of tubulin polymerization, related to the activities displayed by model compounds. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.098

文献信息

• A new family of quinoline and quinoxaline analogues of combretastatins
  作者：Concepción Pérez-Melero、Ana B.S Maya、Benedicto del Rey、Rafael Peláez、Esther Caballero、Manuel Medarde

  DOI：10.1016/j.bmcl.2004.04.098

  日期：2004.7

  The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In this paper we show that the 6- or 7-quinolyl systems can in turn replace both cyclic moieties, keeping in the first case most of the potency as cytotoxic agent and in the second case as inhibitor of tubulin polymerization, related to the activities displayed by model compounds. (C) 2004 Elsevier Ltd. All rights reserved.