2-bromo-9-phenyl-5,6,7,8-tetrahydroacridine | 1256344-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-bromo-9-phenyl-5,6,7,8-tetrahydroacridine
• 英文别名: 7-bromo-9-phenyl-1,2,3,4-tetrahydroacridine
• CAS: 1256344-76-9
• 化学式: C₁₉H₁₆BrN
• 分子量: 338.247
• InChiKey: BXEKMVPGEPRPNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (7-bromohept-1-yn-1-yl)benzene 在 copper(I) oxide 、 sodium azide 作用下， 以 二甲基亚砜 、 1,2-二氯乙烷 为溶剂， 反应 60.0h， 生成 2-bromo-9-phenyl-5,6,7,8-tetrahydroacridine
  参考文献：
  名称：

  An Unprecedented Tandem Annulation of ω-Azido-1-alkynes with Diaryl­iodonium Salts: A Facile Synthesis of Polycyclic Quinolines

  摘要：

  Polysubstituted quinolines are synthesized through an unprecedented cascade annulation of -azido-1-alkynes with diaryliodonium salts, which serve as C2-building blocks. The reaction proceeds smoothly and is catalyzed by Cu(I) catalysts to give various quinolines in good isolated yields with simple operation under mild conditions.

  DOI：

  10.1055/s-0034-1379248

文献信息

• One-Pot Three-Component Synthesis of 6-Bromoquinolines and 6-Iodoquinolines
  作者：Li-Qiang Wu、Xiao Wang、Wei-Wei Ma、Fu-Lin Yan

  DOI：10.1002/jccs.201000086

  日期：2010.8

  AbstractThree‐component one‐pot synthesis of some novel 6‐bromoquinolines 5a‐5h involving the treatment of 2‐aminobenzophenone, α‐methylene carbonyl compounds, and tetrabutyl‐ammonium tribromide was achieved, and this reaction was extended to the preparation of 6‐iodoquinolines 6a‐6e by a three‐component reaction 2‐aminobenzophenone, α‐methylene carbonyl compounds, and benzyltrimethylammonium dichloroiodate in the presence of ZnCl2.