N-acetyl-D-glucosamine | 32450-89-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-acetyl-D-glucosamine
• 英文别名: N-Acetylglucopyranosylamine；N-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]acetamide
• CAS: 32450-89-8
• 化学式: C₈H₁₅NO₆
• 分子量: 221.21
• InChiKey: IBONACLSSOLHFU-KEWYIRBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-heptylglucosylamine 在 乙酸酐 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-acetyl-D-glucosamine
  参考文献：
  名称：

  N-alkyl, n-acetylglycosylamines

  摘要：

  该发明涉及具有以下式的N-烷基、N-乙酰基糖胺：其中R.sub.1代表从葡萄糖、半乳糖、乳糖或赤霉糖中选择的还原糖残基；R.sub.2是一个烷基基团，可以是直链或支链，含有1至24个碳原子，最好含有8至18个碳原子，但要注意，当R.sub.1是乳糖残基时，R.sub.2则与壬基基团不同。这些化合物可用作表面活性剂。

  公开号：

  US05539091A1

文献信息

• A method for derivatizing a 1-amino-1-deoxyoligosaccharide
  申请人：Genzyme Corporation

  公开号：EP0606925A2

  公开（公告）日：1994-07-20

  A method for derivatizing a 1-amino-1-deoxyoligosaccharide comprising reacting said oligosaccharide with an electrophilic reagent, in particular a fluorescent electrophilic reagent.

  使 1-氨基-1-脱氧寡糖衍生化的方法，包括使所述寡糖与亲电试剂，特别是荧光亲电试剂发生反应。
• METHOD FOR EXTRACTING SUBSTANCE FROM FECES SAMPLE
  申请人：Keio University

  公开号：EP3348988A1

  公开（公告）日：2018-07-18

  An object of the present invention is to provide a more practical method for extracting substances from a fecal sample. More specifically, an object of the present invention is to provide a method for extracting substances from a fecal sample, the method being suitable for conducting analyses such as metabolomic analysis using mass spectrometry or nuclear magnetic resonance spectrometry, and metagenomic analysis using a next-generation sequencer. The present invention provides a method for extracting one or more substances from a fecal sample, comprising the following steps A to C: step A: a step of suspending the fecal sample in any one of the following solvents (a) to (g) to obtain a suspension: (a) a solvent comprising an aqueous solvent and a hydrophilic organic solvent; (b) a solvent comprising an aqueous solvent and a hydrophobic organic solvent; (c) a solvent comprising an aqueous solvent, a hydrophilic organic solvent and a hydrophobic organic solvent; (d) a solvent comprising a hydrophilic organic solvent; (e) a solvent comprising a hydrophobic organic solvent; (f) a solvent comprising a hydrophilic organic solvent and a hydrophobic organic solvent; and (g) a solvent consisting of water; step B: a step of separating a liquid layer comprising the solvent from the suspension; and step C: a step of removing proteins from the liquid layer and then obtaining the one or more substances.

  本发明的目的是提供一种更实用的从粪便样本中提取物质的方法。更具体地说，本发明的目的是提供一种从粪便样本中提取物质的方法，该方法适用于进行分析，例如使用质谱或核磁共振谱进行代谢组分析，以及使用新一代测序仪进行元基因组分析。本发明提供了一种从粪便样品中提取一种或多种物质的方法，包括以下步骤 A 至 C： 步骤 A：将粪便样品悬浮在以下溶剂（a）至（g）中的任一种溶剂中，以获得悬浮液：(a) 由水溶剂和亲水性有机溶剂组成的溶剂； (b) 由水溶剂和疏水性有机溶剂组成的溶剂； (c) 由水溶剂、亲水性有机溶剂和疏水性有机溶剂组成的溶剂；(d) 由亲水性有机溶剂组成的溶剂； (e) 由疏水性有机溶剂组成的溶剂； (f) 由亲水性有机溶剂和疏水性有机溶剂组成的溶剂；以及 (g) 由水组成的溶剂； 步骤 B：从悬浮液中分离出包含溶剂的液层的步骤；以及 步骤 C：从液层中去除蛋白质，然后获得一种或多种物质的步骤。
• Method for extracting substance from feces sample
  申请人：KEIO UNIVERSITY

  公开号：US10927401B2

  公开（公告）日：2021-02-23

  A method for extracting substances from a fecal sample using mass spectrometry or nuclear magnetic resonance spectrometry, and metagenomic analysis using a next-generation sequencer. The method includes step A: a step of suspending the fecal sample in any one of the following solvents (a) to (g) to obtain a suspension: (a) a solvent comprising an aqueous solvent and a hydrophilic organic solvent; (b) a solvent comprising an aqueous solvent and a hydrophobic organic solvent; (c) a solvent comprising an aqueous solvent, a hydrophilic organic solvent and a hydrophobic organic solvent; (d) a solvent comprising a hydrophilic organic solvent; (e) a solvent comprising a hydrophobic organic solvent; (f) a solvent comprising a hydrophilic organic solvent and a hydrophobic organic solvent; and (g) a solvent consisting of water; step B: a step of separating a liquid layer comprising the solvent from the suspension; and step C: a step of removing proteins from the liquid layer and then obtaining the one or more substances.

  一种利用质谱法或核磁共振谱法从粪便样品中提取物质并利用新一代测序仪进行元基因组分析的方法。该方法包括步骤 A：将粪便样品悬浮在以下溶剂（a）至（g）中的任一种溶剂中，以获得悬浮液：(a) 由水性溶剂和亲水性有机溶剂组成的溶剂； (b) 由水性溶剂和疏水性有机溶剂组成的溶剂； (c) 由水性溶剂、亲水性有机溶剂和疏水性有机溶剂组成的溶剂；(d) 由亲水性有机溶剂组成的溶剂； (e) 由疏水性有机溶剂组成的溶剂； (f) 由亲水性有机溶剂和疏水性有机溶剂组成的溶剂；以及 (g) 由水组成的溶剂； 步骤 B：从悬浮液中分离出包含溶剂的液层的步骤；以及 步骤 C：从液层中去除蛋白质，然后获得一种或多种物质的步骤。
• H. pylori fucosyltransferases
  申请人：Simala-Grant Joanne

  公开号：US20050164338A1

  公开（公告）日：2005-07-28

  This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori . The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, glycoproteins, and glycolipids.

  本发明提供了来自以下细菌的岩藻糖基转移酶的核酸和氨基酸序列 幽门螺杆菌 .本发明还提供了利用岩藻糖基转移酶合成寡糖、糖蛋白和糖脂的方法。
• Enlargement of mucocutaneous or cutaneous organs and sites with topical compositions
  申请人：Yu J. Ruey

  公开号：US20050171194A1

  公开（公告）日：2005-08-04

  Compositions comprising a hydroxycarboxylic acid, N-acyl-aldosamine, N-acylamino acid or related compound on topical application are beneficial to plump and pout lips, enhance and firm eyelids, enlarge and augment breasts, elongate and expand penis. Because of antioxidant property, certain hydroxycarboxylic acids, N-acyl-aldosamines, N-acylamino acids and related compounds also are useful for topical administration to prevent occurrence of breast cancer or other forms of tumors and cancers.

  由羟基羧酸、N-酰基-醛糖胺、N-酰基氨基酸或相关化合物组成的组合物在局部使用时有利于丰满嘴唇、增强和紧实眼睑、增大和隆起乳房、拉长和扩张阴茎。由于具有抗氧化性，某些羟基羧酸、N-酰基醛胺和 N-酰基氨基酸及相关化合物还可用于局部用药，以预防乳腺癌或其他形式的肿瘤和癌症的发生。