3-hydroxy-4-methylcinnamic acid | 1223570-08-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-hydroxy-4-methylcinnamic acid
• 英文别名: 3-(3-Hydroxy-4-methylphenyl)prop-2-enoic acid；(E)-3-(3-hydroxy-4-methylphenyl)prop-2-enoic acid
• CAS: 1223570-08-8
• 化学式: C₁₀H₁₀O₃
• 分子量: 178.188
• InChiKey: AGXCRKZHIGECTB-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-4-methylcinnamic acid 在 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  肉桂酸苯胺作为新的线粒体通透性转变孔隙抑制剂，具有体内缺血再灌注损伤的保护作用

  摘要：

  在这个帐户中，我们报告了一系列取代的肉桂酸苯胺的开发，这些肉桂酸代表了一类新型的线粒体通透性过渡孔（mPTP）抑制剂。最初的类别扩展导致建立了活性的基本结构要求，并鉴定了具有比标准抑制剂环孢菌素-A（CsA）更高的抑制能力的衍生物。这些化合物可响应多种刺激（包括钙超载，氧化应激和硫醇交联剂）抑制mPTP的开放。肉桂酸苯胺类mPTP抑制剂的活性被证明与CsA的活性相加，提示这些抑制剂的分子靶标不同于环绿素D。给出了（E）-3-（4-氟-3-羟基-苯基）-的体外和体内数据N-萘-1-基丙烯酰胺22是该系列中最引人关注的化合物之一，能够减轻mPTP的开放度并限制兔子在急性心肌梗塞模型中的再灌注损伤。

  DOI：

  10.1021/jm500547c

文献信息

• PROCESS FOR THE PREPARATION OF ADVANTAME
  申请人：Divi's Laboratories Limited

  公开号：US20160304439A1

  公开（公告）日：2016-10-20

  A novelprocess for the preparation of N—[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-α-aspartyl]-L-phenylalanine-1-methyl ester is described. It comprises, reacting isovanillin or its derivative with vinyl acetate followed by reductive condensation with L-[α-aspartyl]-L-phenylalanine-1-methyl ester.

  描述了一种制备N-[N-[3-(3-羟基-4-甲氧基苯基)-丙基]-L-α-天冬氨酰]-L-苯丙氨酸-1-甲酯的新型工艺。该工艺包括，将异香草醛或其衍生物与乙酸乙烯酯反应，然后与L-[α-天冬氨酰]-L-苯丙氨酸-1-甲酯进行还原缩合。
• Altering levels of anti-nutrient factors in plants
  申请人：Hannoufa Abdelali

  公开号：US20070174933A1

  公开（公告）日：2007-07-26

  A method for reducing the level of one or more than one protein in a plant or a tissue within the plant, and plants with reduced levels of target proteins are provided. The method involves introducing a nucleic acid sequence into the plant, where the nucleic acid sequence comprises a regulatory region operatively associated with a silencing nucleotide sequence. The expression of the silencing nucleotide sequence reduces or eliminates the expression of two or more than two enzymes involved in the synthesis of the one or more than one protein. The reduced level of the one or more than one protein may be determine by comparing the level of the one or more than one protein in the plant, or a tissue of the plant, with a level of the one ore more than one protein in a second plant, or the tissue from the second plant, that does not express the nucleic acid sequence. Plants and seeds obtained from plants with reduced levels of target proteins, and reduced anti-nutrient factors are also provided
• Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Dioxy Compound And Uses Thereof
  申请人：Quinlan Jason

  公开号：US20130157317A1

  公开（公告）日：2013-06-20

  The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a dioxy compound. The present invention also relates to methods of using the compositions.
• DECOCTION OF OLIVE LEAVES
  申请人：Pesle Livio

  公开号：US20170080040A1

  公开（公告）日：2017-03-23

  A decoction of olive leaves comprises an aqueous composition containing at least from about 500 mg/liter to about 3,000 mg/liter of oleuropein, from about 100 mg/liter to about 300 mg/liter of hydroxytyrosol, from about 90 mg/liter to about 280 mg/liter of tyrosol, from about 400 mg/liter to about 1,800 mg/liter of elenolic acid.
• US9394555B2
  申请人：——

  公开号：US9394555B2

  公开（公告）日：2016-07-19