碘普胺杂质B | 76350-28-2

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 碘普胺杂质B
• 中文别名: 5-乙酰氨基-N,N'-二(2,3-二羟基丙基)-2,4,6-三碘-N-甲基间苯二甲酰胺；碘普罗胺相关物质B
• 英文名称: Desmethoxy Iopromide
• 英文别名: 5-acetamido-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-3-N-methylbenzene-1,3-dicarboxamide
• CAS: 76350-28-2
• 化学式: C₁₇H₂₂I₃N₃O₇
• 分子量: 761.1
• InChiKey: USZSPRUWTHXRRB-UHFFFAOYSA-N

物化性质

• 熔点：
  246-248°C
• 沸点：
  834.3±65.0 °C(Predicted)
• 密度：
  2.230±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  159
• 氢给体数：
  6
• 氢受体数：
  7

安全信息

• WGK Germany：
  3

文献信息

• REACTIVE MULTI-ARM POLYMERS HAVING BRANCHED END GROUPS
  申请人：Boston Scientific Scimed Inc.

  公开号：US20210060183A1

  公开（公告）日：2021-03-04

  In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

  在某些方面，本公开涉及一种聚合物，其包括多个聚合物臂，其中聚合物臂的第一部分包括反应性末端基团，聚合物臂的第二部分包括分支末端基团，该分支末端基团包括多个共价连接的诊断和/或治疗基团，例如放射对比剂或放射性基团。其他方面涉及一种系统，该系统包括（a）包含这种聚合物的第一组成份和（b）包含具有与多臂聚合物的反应性末端基团反应的反应性功能基团的多功能化合物的第二组成份。还有其他方面涉及（a）这种聚合物和（b）包含与多臂聚合物的反应性末端基团反应的功能性基团的多功能化合物的交联反应产物。
• RADIOPAQUE MULTI-ARMED POLYMERS AND COMPOSITIONS, SYSTEMS AND METHODS PERTAINING TO THE SAME
  申请人：Boston Scientific Scimed Inc.

  公开号：EP4021513A1

  公开（公告）日：2022-07-06
• [EN] RADIOPAQUE MULTI-ARMED POLYMERS AND COMPOSITIONS, SYSTEMS AND METHODS PERTAINING TO THE SAME<br/>[FR] POLYMÈRES MULTI-BRAS RADIO-OPAQUES ET COMPOSITIONS, SYSTÈMES ET PROCÉDÉS ASSOCIÉS
  申请人：BOSTON SCIENT SCIMED INC

  公开号：WO2021041230A1

  公开（公告）日：2021-03-04

  In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.
• [EN] REACTIVE MULTI-ARM POLYMERS HAVING BRANCHED END GROUPS<br/>[FR] POLYMÈRES À PLUSIEURS BRAS RÉACTIFS AYANT DES GROUPES TERMINAUX RAMIFIÉS
  申请人：BOSTON SCIENT SCIMED INC

  公开号：WO2021041234A1

  公开（公告）日：2021-03-04

  In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.