formyl-triglycine | 23380-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: formyl-triglycine
• 英文别名: N^α-formylglycyl-glycyl-glycine；N-formyltriglycine；N-Formylglycylglycylglycine；2-[[2-[(2-formamidoacetyl)amino]acetyl]amino]acetic acid
• CAS: 23380-20-3
• 化学式: C₇H₁₁N₃O₅
• 分子量: 217.181
• InChiKey: ZKWMBLGJLDIMEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  formyl-triglycine 在 palladium(II) oxide 盐酸 、 氢溴酸 、 氢气 、 三乙胺 、 氯甲酸异丁酯 作用下， 以 甲醇 、 溶剂黄146 为溶剂， -10.0~25.0 ℃ 、101.33 kPa 条件下， 反应 160.67h， 生成 L-arginyl-L-arginyl-glycyl-glycyl-glycyl-L-arginyl-L-arginine methyl ester
  参考文献：
  名称：

  Avdyukova, N. V.; Shirokova, A. G.; Radina, L. B., Journal of general chemistry of the USSR, 1982, vol. 52, # 1, p. 156 - 161

  摘要：

  DOI：
• 作为产物：
  描述：

  甲酸 、 甘氨酰-甘氨酰-甘氨酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 formyl-triglycine
  参考文献：
  名称：

  以三(三甲基甲硅烷基)亚磷酸酯为基础合成新型含N-(二膦酰基甲基)肽

  摘要：

  在温和条件下，在有效催化剂三甲基甲硅烷基三氟甲磺酸酯存在下，通过亚磷酸三（三甲基甲硅烷基）酯与适当的N-甲酰基肽反应，以高产率合成了新的官能化N- （二膦酰基甲基）肽。提出了用于形成产物的催化方案。所得化合物作为有前途的生物活性物质和有效配体是令人感兴趣的。

  DOI：

  10.1007/s11172-022-3616-x

文献信息

• STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20180200173A1

  公开（公告）日：2018-07-19

  A solid base material for external use on skin that has a breaking strength sufficiently high to be usable as a stick-shaped base material or the like. A solid base material for external use on skin containing a lipid peptide compound including at least one of compound of Formula (1), the similar compound thereof and the pharmacologically usable salts thereof; water; and a 1,3-alkanediol; wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number from 1 to 4, and X is amino group, guanidino group, -CONH 2 group, or a 5-membered ring group or 6-membered ring group optionally having one to three nitrogen atoms or a fused heterocyclic group composed of the 5-membered ring and the 6-membered ring.

  一种用于外用于皮肤的固体基材料，其断裂强度足够高，可用作棒状基材料或类似物。一种用于外用于皮肤的固体基材料，包含一个脂肽化合物，其中至少包括公式（1）的化合物、类似的化合物及其药学可用的盐；水；和1,3-烷二醇；其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n是1至4之间的数字，而X是氨基、鸟氨酸基、-CONH2基团或具有1至3个氮原子或由5-成员环和6-成员环组成的融合杂环基团中的5-成员环基团或6-成员环基团。
• STICK-SHAPED BASE MATERIAL HAVING HIGH WATER CONTENT
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200197284A1

  公开（公告）日：2020-06-25

  A stick-shaped base material capable of having a breaking strength required for a stick-shaped base material even when the amount of a lipid peptide compound contained therein is reduced, including: a surfactant; water; a lipid peptide compound including at least one of compound of the following Formula (1) and similar compound thereof or pharmaceutically usable salts of the compounds: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, wherein n is a number of 1 to 4, and X is an amino group, guanidine group, or a —CONH 2 group, or a 5-membered or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the rings; a 1,2-alkanediol or a 1,3-alkanediol; at least one fatty acid; and an alginic acid derivative.

  一种棒状基材料，即使其中含有脂肽化合物的量减少，仍能具有棒状基材料所需的断裂强度，包括：表面活性剂；水；脂肽化合物，其中包括以下式（1）的化合物和类似化合物或其药用盐之一：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是—（CH2）n—X基团，其中n为1至4的数字，X是氨基、鸟氨酸基或—CONH2基团，或者是具有1至3个氮原子的5元或6元环，或者是由这些环组成的融合杂环；1,2-癸二醇或1,3-癸二醇；至少一种脂肪酸；和藻酸衍生物。
• THICKENED COMPOSITION CONTAINING LIPID PEPTIDE-TYPE COMPOUND
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170042783A1

  公开（公告）日：2017-02-16

  A thickened composition that does not lose viscosity even in the presence of an organic acid. A thickened composition, including a polyhydric alcohol, water, an organic acid, and a lipid peptide-type compound containing at least one of a compound of Formula (1) to Formula (3) below and a pharmaceutically usable salt of compound of Formula (1) to Formula (3), where R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group that optionally has a C 1-2 branched chain, R 3 is a —(CH 2 ) n —X group, n is a number of 1 to 4, X is an amino group, guanidino group, —CONH 2 group, a 5-membered ring group optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring group optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle group that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s).

  这是一种增稠的组合物，即使存在有机酸也不会失去粘度。该增稠组合物包括多元醇、水、有机酸和脂肽类化合物，该化合物含有以下化合物之一或化合物的药用盐：式（1）至式（3）中的化合物，其中R1是C9-23脂肪基，R2是氢原子或C1-4烷基，可选地具有C1-2支链，R3是—（CH2）n—X基团，n是1到4的数字，X是氨基团、鸟氨酸基团、—CONH2基团、一个含有1到3个氮原子的5元环基团、一个含有1到3个氮原子的6元环基团或含有一个5元环和一个6元环的缩合杂环基团，可选地含有1到3个氮原子。
• STICK-TYPE SOLID BASE MATERIAL FOR EXTERNAL APPLICATION TO SKIN
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200138679A1

  公开（公告）日：2020-05-07

  A solid base material is capable of preventing “sweating” over time. A stick-type solid base material for external application to skin including a lipidic peptide compound including at least one of compounds of the following Formulae (1), the similar compounds thereof or pharmaceutically usable salts of the compounds, a surfactant, water, an oily base, and a saturated or unsaturated monohydric alcohol having a carbon atom number of 8 to 30: wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group optionally having a C 1 or C 2 branched chain; and R 3 is a —(CH 2 ) n —X group, n is a number of 1 to 4, and X is an amino group, a guanidino group, a —CONH 2 group, or a 5-membered ring or 6-membered ring optionally having one to three nitrogen atoms or a fused heterocyclic ring composed of the 5-membered ring and the 6-membered ring.

  一种固体基材料能够防止“出汗”现象。一种用于外部涂抹于皮肤的棒状固体基材料，包括脂肪肽化合物，其中至少包括以下化合物之一，其类似化合物或化合物的药用盐，表面活性剂，水，油性基质和具有8到30个碳原子数的饱和或不饱和单醇：其中R1是C9-23脂肪基；R2是氢原子或C1-4烷基，可选地具有C1或C2支链；R3是-（CH2）n-X基团，其中n是1到4的数字，X是氨基团，鸟氨酸基团，-CONH2基团，或具有1到3个氮原子的5元环或6元环，或由5元环和6元环组成的融合杂环。
• TRANSDERMALLY ABSORBABLE BASE MATERIAL CONTAINING LIPID PEPTIDE COMPOUND
  申请人：KYUSHU UNIVERSITY

  公开号：US20180021250A1

  公开（公告）日：2018-01-25

  A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein R 1 is a C 9-23 aliphatic group; R 2 is a hydrogen atom or a C 1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; R 3 is a —(CH 2 ) n —X group; n is a number of 1 to 4; and X is amino group, guanidino group, —CONH 2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.

  一种可经皮吸收的基础材料，包括：脂肽化合物，其中包括下式（1）的化合物之一及其类似化合物或药用可用盐；表面活性剂；特定的多羟基醇；脂肪酸；和水。其中，R1是C9-23脂肪族基；R2是氢原子或C1-4烷基，可选地具有碳原子数为1或2的支链；R3是-（CH2）n-X基团；n为1至4的数字；X是氨基团，鸟氨酸基团，-CONH2基团，或者是一个可选地具有1至3个氮原子的5元环基团，可选地具有1至3个氮原子的6元环基团，或者是由一个5元环基团和一个6元环基团组成的缩合杂环基团，可选地具有1至3个氮原子。