Octadecyl-t-butylaether | 61548-84-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Octadecyl-t-butylaether
• 英文别名: tert.-Butyl-octadecylaether；Octadecyl-tert.-butyl-aether；1-tert-butoxy-octadecane；Octadecane, 1-(1,1-dimethylethoxy)-；1-[(2-methylpropan-2-yl)oxy]octadecane
• CAS: 61548-84-3
• 化学式: C₂₂H₄₆O
• 分子量: 326.607
• InChiKey: DVFRYFLSZCALRU-UHFFFAOYSA-N

物化性质

• 熔点：
  52.5-53.5 °C
• 沸点：
  369.7±10.0 °C(Predicted)
• 密度：
  0.820±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲基苯磺酸十八醇酯 、 potassium tert-butylate 以 叔丁醇 为溶剂， 生成 Octadecyl-t-butylaether
  参考文献：
  名称：

  Competitive Elimination-Substitution Reactions. Some Dramatic Differences between Bromides and Tosylates

  摘要：

  DOI：

  10.1021/ja01069a020

文献信息

• Amine Cationic Lipids and Uses Thereof
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US20140371293A1

  公开（公告）日：2014-12-18

  The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

  本发明涉及脂质化合物及其用途。具体而言，这些化合物包括一类具有胺基团的阳离子脂质，例如氨基-胺或氨基-酰胺基团。这些脂质化合物可用于体内或体外传递一个或多个药物（例如，多聚阴离子荷载物或反义荷载物，如RNAi药物）。
• Process for formulating an anionic agent
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US11351265B2

  公开（公告）日：2022-06-07

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.

  包含阴离子剂（如含脂微粒中的核酸）的制剂 配制包含阴离子剂（如核酸）的含脂微粒的方法、制备包含阴离子剂（如核酸）的含脂微粒的方法、向有需要的患者治疗递送阴离子剂的方法，其中阴离子剂被配制在本文所述的含脂微粒中。
• Reactions of Potassium t-Butoxide in Dimethyl Sulfoxide. IV.¹ With Primary Tosylates and Halides^*
  作者：Neville F. Wood、Frederic C. Chang

  DOI：10.1021/jo01017a508

  日期：1965.6
• KARLSSON, SUSANNE;HALLBERG, ANDERS;GRONOWITZ, SALO, CHEM. SCR., 28,(1988) N 2, C. 185-189
  作者：KARLSSON, SUSANNE、HALLBERG, ANDERS、GRONOWITZ, SALO

  DOI：——

  日期：——
• PROCESS FOR FORMULATING AN ANIONIC AGENT
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US20150374842A1

  公开（公告）日：2015-12-31

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.