N-(quinolin-8-yl)-2,4-di((E)-styryl)cyclobutane-1-carboxamide | 1571067-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(quinolin-8-yl)-2,4-di((E)-styryl)cyclobutane-1-carboxamide
• CAS: 1571067-08-7
• 化学式: C₃₀H₂₆N₂O
• 分子量: 430.549
• InChiKey: APNSRKCWVSHLFF-QTQCMGGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.85
• 重原子数：
  33.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  41.99
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-(quinolin-8-yl)-2,4-di((E)-styryl)cyclobutane-1-carboxamide 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以96%的产率得到N-(quinolin-8-yl)-2,4-di((E)-styryl)cyclobutane-1-carboxamide
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148
• 作为产物：
  描述：

  8-氨基喹啉 在 silver(I) acetate 、 palladium diacetate 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 15.0h， 生成 N-(quinolin-8-yl)-2,4-di((E)-styryl)cyclobutane-1-carboxamide
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148