4-丙基己醛 | 339061-37-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-丙基己醛
• 英文名称: 4-propylhexanal
• 英文别名: 4-Ethylheptanal
• CAS: 339061-37-9
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: RWBPBFXKJKHLCF-UHFFFAOYSA-N

物化性质

• 沸点：
  183.7±8.0 °C(Predicted)
• 密度：
  0.813±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  辛烯 、 一氧化碳 在 Rh(acac)2(CO)2 、 C₂₁H₂₉P 、 氢气 、 三乙酰基-β-环糊精 作用下， 以 二氧化碳 为溶剂， 80.0 ℃ 、25.33 MPa 条件下， 反应 3.0h， 生成 壬醛 、 2-甲基辛醛 、 4-丙基己醛 、 3-ethylheptanal
  参考文献：
  名称：

  使用全乙酰化 β-环糊精作为增溶剂，在铑上用烷基对供体配体在超临界二氧化碳中加氢甲酰化 1-辛烯

  摘要：

  反应介质中全乙酰化 β-环糊精的存在允许在超临界二氧化碳中 1-辛烯的催化加氢甲酰化中由烷基 P-供体配体修饰的铑物质的溶解度增加。这些结果是通过考虑全乙酰化 β-环糊精和 P-供体配体之间的相互作用来解释的。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200800153

文献信息

• [EN] NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX GLYCOPEPTIDES SEMI-SYNTHÉTIQUES COMME AGENTS ANTIBACTÉRIENS
  申请人：LEAD THERAPEUTICS INC

  公开号：WO2009085562A1

  公开（公告）日：2009-07-09

  Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate or carrying a Hofmann degradation of the primary amide of the 3rd amino acid asparagines with phenyl-bis-trifluoroacetate to give the primary amine. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  本文描述了具有抗菌活性的半合成糖肽，特别是在此处描述的半合成糖肽是通过对一种糖肽（化合物A、化合物B、化合物H或化合物C）或通过在酸性介质中水解母体糖肽的氨基酸-4的二糖基团以获得氨基酸-4单糖；将单糖转化为氨基糖衍生物；酰化这些支架上氨基酸-4氨基取代糖基团上的氨基取代基团；以及将这些支架的大环环上的酸基团转化为某些取代酰胺。关键反应是将适当保护的中间化合物与异氰酸酯处理，或者将第3个氨基酸天冬氨酸的主要酰胺通过苯基-双三氟乙酸酯进行霍夫曼降解以获得主要胺基。还提供了合成这些化合物的方法，含有这些化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。
• FULLERENE DERIVATIVE AND n-TYPE SEMICONDUCTOR MATERIAL
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20180282274A1

  公开（公告）日：2018-10-04

  An object of the present invention is to provide a novel fullerene derivative usable in n-type semiconductor materials for organic thin-film solar cells and the like. The object is achieved by a fullerene derivative represented by formula (1) wherein R 1 represents aryl optionally substituted with at least one substituent, R 2 represents an organic group, R 3 represents an organic group, with the proviso that at least one of R 2 and R 3 is alkyl optionally substituted with at least one substituent or alkyl ether optionally substituted with at least one substituent, R 4 represents hydrogen or an organic group, and a ring A represents a fullerene ring.

  本发明的目的是提供一种新型富勒烯衍生物，可用于有机薄膜太阳能电池等n型半导体材料。该目的通过由式（1）表示的富勒烯衍生物实现，其中R1代表芳基，可选择地取代至少一个取代基，R2代表有机基团，R3代表有机基团，但至少R2和R3中的一个是烷基，可选择地取代至少一个取代基或烷基醚，可选择地取代至少一个取代基，R4代表氢或有机基团，环A代表一个富勒烯环。
• Rhizoxin derivates and their use as anti-tumor agents
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0350315A1

  公开（公告）日：1990-01-10

  Rhizoxin and rhizoxin-2-ene derivatives of formula (I): [in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulphur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkyl­phosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R¹ and R², where R¹ and R² are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono] have valuable anti-tumour activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.

  式(I)的根肿灵和根肿灵-2-烯衍生物： 其中n 为 1 至 25；A 为额外键或氧，X 为氧、硫、氮或羰基；和 R 是氢、具有 1 至 25 个碳原子的羧酰基、具有 2 至 26 个碳原子的烷氧羰基、膦酰基、烷基膦酰基（其中烷基部分具有 1 至 25 个碳原子）、二烷基膦酰基（其中每个烷基部分具有 1 至 25 个碳原子）、具有 1 至 25 个碳原子的烷基、或当 X 代表氮原子时，R 为 R¹ 和 R²，其中 R¹ 和 R²为氢、烷基、酰基、烷氧羰基、膦酰基、烷基膦酰基或二烷基膦酰基]具有重要的抗肿瘤活性。它们可通过 rhizoxin 或 rhizoxin-2-ene 的酰化反应制备。
• Fullerene derivative and n-type semiconductor material
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US10894770B2

  公开（公告）日：2021-01-19

  An object of the present invention is to provide a novel fullerene derivative usable in n-type semiconductor materials for organic thin-film solar cells and the like. The object is achieved by a fullerene derivative represented by formula (1) wherein R1 represents aryl optionally substituted with at least one substituent, R2 represents an organic group, R3 represents an organic group, with the proviso that at least one of R2 and R3 is alkyl optionally substituted with at least one substituent or alkyl ether optionally substituted with at least one substituent, R4 represents hydrogen or an organic group, and a ring A represents a fullerene ring.

  本发明的目的是提供一种新型富勒烯衍生物，可用于有机薄膜太阳能电池等的 n 型半导体材料。由式（1）表示的富勒烯衍生物可实现上述目的 其中 R1 代表至少被一个取代基任选取代的芳基，R2 代表有机基团，R3 代表有机基团，但 R2 和 R3 中至少有一个是至少被一个取代基任选取代的烷基或至少被一个取代基任选取代的烷基醚，R4 代表氢或有机基团，环 A 代表富勒烯环。
• BISPHOSPHITVERBINDUNGEN, DEREN METALLKOMPLEXE UND VERWENDUNG DER VERBINDUNGEN UND KOMPLEXE IN DER OLEFINHYDROFORMYLIERUNG
  申请人：Oxeno Olefinchemie GmbH

  公开号：EP1294731A1

  公开（公告）日：2003-03-26