ethyl zinc isopropanolate | 18996-46-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl zinc isopropanolate
• 英文别名: Aethyl-isopropoxy-zink；Ethylzink-isopropoxid；ethylzinc alkoxide of 2-propanol；EtZnO(i)Pr
• CAS: 18996-46-8
• 化学式: C₅H₁₂OZn
• 分子量: 153.54
• InChiKey: ZNKKJQSIIWYNCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.85
• 重原子数：
  7.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (rac)-2-{[2′-(dimethylamino)-1,1′-binaphthyl-2-ylimino]-methyl}-6-bromo-4-tert-butylphenol 、 ethyl zinc isopropanolate 以 甲苯 为溶剂， 以57.6%的产率得到[Zn((rac)-2-{[2′-(dimethylamino)-1,1′-binaphthyl-2-ylimino]-methyl}-6-bromo-4-tert-butylphenolate)2]
  参考文献：
  名称：

  的开环聚合外消旋-丙交酯和α甲基三亚甲基碳酸酯通过基于联萘iminophenolate配体衍生的镁和锌配合物催化†

  摘要：

  一系列外消旋的2-[（（2'-（二甲氨基）联萘-2-ylimino）甲基] -4-R 2 -6-R 1-苯酚（L 1 H–L 6 H）与1当量反应。Mg [N（SiMe 3）2 ] 2或Zn [N（SiMe 3）2 ] 2形成三个杂硅镁硅酰胺基络合物[（L 4-6）MgN（SiMe 3）2 ]（4a：R 1 = R 2 =枯基; 5a：R 1 = CPh 3，R 2=我；图6a：R 1＝ CPh 3，R 2＝t Bu）和一种杂配硅烷基硅铝酰胺基络合物[（L 4）ZnN（SiMe 3）2 ]（4b：R 1＝ R 2＝枯基）。通过X射线衍射研究进一步证实了配合物4a，4b和同型锌配合物（L 5）2 Zn（5b'）的分子结构。固态的杂镁复合物4a具有被配体的三个供体原子和一个双（三甲基甲硅烷基）酰胺基螯合的四配位金属核；然而，杂配锌配合物4b具有被配体的两个供体原子和一个双（三甲基甲硅烷基）酰胺

  DOI：

  10.1039/c5dt00158g
• 作为产物：
  描述：

  diethylzinc 、 异丙醇 以 甲苯 为溶剂， 以85%的产率得到ethyl zinc isopropanolate
  参考文献：
  名称：

  Lactide Polymerization with Chiral β-Diketiminate Zinc Complexes

  摘要：

  N,N'-Di(S-phenylethyl)-2-amino-4-iminopent-2-ene, S,S-nacnac(CH(Me)Ph)H, 1a, and N,N'-dibenzyl-2-amino-4-iminopent-2-ene, nacnac(Bn)H, 1b, react with ZnEt(2) to form the corresponding nacnacZnEt complexes 2a and 2b. Neither complex is reactive with 2-propanol or methyl lactate to produce the corresponding alkoxide complexes. In reactions with 2b, ligand redistribution occurs and nacnaca(2)(Bn)Zn was obtained. Reaction of 1a and 1b with Zn(N(SiMe(3))(2))(2) yielded nacnacZnN(SiMe(3))(2), 6a and 6b. From further reactions with 2-propanol nacnacZnOiPr, 7a and 7b, were obtained. Both complexes were catalytically active for polymerization of rac-lactide with apparent first-order rate constants of k(app) = 0.013-0.019 min(-1) and 0.019-0.038 min(-1) for 7a and 7b, respectively. Obtained polymers were highly heterotactic, with P(r) = 0.84-0.87 (7a) and 0.65-0.71 (7b). Analysis of remaining monomer after 75% conversion showed negligible ee and indicates that chiral 7a does not show enantioselectivity in rac-lactide polymerization. Complex 7a, but not 7b, catalyzes unselective transesterification of the polymer during and after polymerization. PLA microstructures in polymerizations with 7b were independent of temperature (23 or 0 degrees C) or monomer/catalyst ratio (100:1 to 400:1). However, slightly higher Pr values were obtained in the presence of 10-100 equiv of MeCN or pyridine. Complexes nacnac(2)(Bn)ZN, 2b, 6b, and 7a were characterized by an X-ray diffraction study.

  DOI：

  10.1021/om100154w
• 作为试剂：
  描述：

  6-氧代己酸甲酯 在 ethyl zinc isopropanolate 、 4 A molecular sieve 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 5-(5-methoxycarbonylpentanoyloxymethyl)-6-oxoundecanedioic acid dimethyl ester
  参考文献：
  名称：

  Organozinc alkoxide-promoted aldol-Tishchenko reaction of aliphatic aldehydes: an expedient entry to prepare the α-methylene ketones

  摘要：

  i-PrOZnEt is an excellent reagent to promote the aldol-Tishchenko reaction of the aliphatic aldehydes tethered with other labile functional groups. The 1,3-diol monoesters 4 were formed as the major products, which could be converted to alpha-methylene ketones 7 in two steps in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.076