per-6-(pyridin-2-ylmethylamino)per-6-deoxy-β-cyclodextrin | 201533-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: per-6-(pyridin-2-ylmethylamino)per-6-deoxy-β-cyclodextrin
• CAS: 201533-70-2
• 化学式: C₈₄H₁₁₂N₁₄O₂₈
• 分子量: 1765.89
• InChiKey: ZSCBVPADAAKUJO-SABFSVKMSA-N

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以60 mg的产率得到per-6-(pyridin-2-ylmethylamino)per-6-deoxy-β-cyclodextrin
  参考文献：
  名称：

  Click synthesis of estradiol–cyclodextrin conjugates as cell compartment selective estrogens

  摘要：

  Cyclodextrin (CD) is a well known drug carrier and excipient for enhancing aqueous solubility. CDs themselves are anticipated to have low membrane permeability because of relatively high hydrophilicity and molecular weight. CD derivatization with 17-beta estradiol (E-2) was explored extensively using a number of different click chemistries and the cell membrane permeability of synthetic CD-E-2 conjugate was explored by cell reporter assays and confocal fluorescence microscopy. In simile with reported dendrimer-E-2 conjugates, CD-E-2 was found to be a stable, extranuclear receptor selective estrogen that penetrated into the cytoplasm. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.11.046