| 1221895-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1221895-71-1
• 化学式: C₂₃H₂₀Cl₂N₄O₂S
• 分子量: 487.409
• InChiKey: BTXVUPIFDRQPTH-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 盐酸甲胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists

  摘要：

  The synthesis, structure-activity relationship (SAR) studies and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles are described. The target compounds 6-18 represent a novel class of potent and selective CB1 receptor antagonists. Based on X-ray diffraction data, the orally active 17 is shown to elicit a different intramolecular H-bonding mode as compared to ibipinabant (3) and SLV330 (4). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.049