N-(1-(3-bromophenyl)-3-(4-nitrophenyl)-3-oxopropyl)acetamide | 1378871-15-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: N-(1-(3-bromophenyl)-3-(4-nitrophenyl)-3-oxopropyl)acetamide
• CAS: 1378871-15-8
• 化学式: C₁₇H₁₅BrN₂O₄
• 分子量: 391.221
• InChiKey: WRMPMQYLEHXVFE-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  间溴苯甲醛 、 乙酰氯 、 对硝基苯乙酮 、 乙腈 在 aluminum potassium sulfate dodecahydrate 作用下， 反应 2.0h， 以80%的产率得到N-(1-(3-bromophenyl)-3-(4-nitrophenyl)-3-oxopropyl)acetamide
  参考文献：
  名称：

  KAl (SO₄)₂.12H₂O or KHSO₄: Efficient and Inexpensive Catalysts for the One-Pot Synthesis of β-Acetamido Ketones by Dakin–West Reaction

  摘要：

  Aromatic aldehydes were reacted in a vessel with enolizable ketones, acetonitrile, and acetyl chloride at ambient temperature in the presence of KAl(SO4)(2)center dot 12H(2)O to furnish the corresponding beta-acetamido ketones in excellent yields. KHSO4 has also been used as another catalyst for this reaction at room temperature. Key features of this methodology are operational simplicity, mild reaction conditions, and excellent yields.

  DOI：

  10.1080/15533174.2011.609514