[2-Methyl-prop-(E)-ylidene]-prop-2-ynyl-amine | 22483-20-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [2-Methyl-prop-(E)-ylidene]-prop-2-ynyl-amine
• 英文别名: 2-methyl-N-prop-2-ynylpropan-1-imine
• CAS: 22483-20-1
• 化学式: C₇H₁₁N
• 分子量: 109.171
• InChiKey: JUCURQHZDZBNEY-UHFFFAOYSA-N

物化性质

• 沸点：
  140.5±32.0 °C(Predicted)
• 密度：
  0.74±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [2-Methyl-prop-(E)-ylidene]-prop-2-ynyl-amine 以 水 为溶剂， 生成 炔丙胺
  参考文献：
  名称：

  Polar effects on the formation of imines from isobutyraldehyde and primary aliphatic amines

  摘要：

  DOI：

  10.1021/jo00827a010
• 作为产物：
  描述：

  炔丙胺 在 /BRN= 605330/ 作用下， 以 水 为溶剂， 生成 [2-Methyl-prop-(E)-ylidene]-prop-2-ynyl-amine
  参考文献：
  名称：

  Polar effects on the formation of imines from isobutyraldehyde and primary aliphatic amines

  摘要：

  DOI：

  10.1021/jo00827a010

文献信息

• Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach
  作者：Martin C N Brauer、Ricardo A W Neves Filho、Bernhard Westermann、Ramona Heinke、Ludger A Wessjohann

  DOI：10.3762/bjoc.11.4

  日期：——

  A library of ten 1,3-diyne-linked peptoids has been synthesized through an Ugi four-component reaction (U-4CR) followed by a copper-catalysed alkyne homocoupling (Glaser reaction). The short and chemoselective reaction sequence allows generating diverse (pseudo) dimeric peptoids. A combinatorial version allows the one-pot preparation of, e.g., six-compound-libraries of homo- and heterodimers verified by ESI-MS and HPLC. In a preliminary evaluation, some compounds display moderate activity against the Gram-positive bacterium Bacillus subtilis.

  已合成了十种1,3-二炔基连接的肽酰胺图书馆，通过Ugi四组分反应（U-4CR）后接铜催化的炔烃同偶联（Glaser反应）。这种简短和化学选择性的反应序列允许生成多样化的（伪）二聚体肽酰胺。一种组合版本允许一锅法制备例如六种化合物图书馆的同源和异源二聚体，通过ESI-MS和HPLC验证。在初步评估中，一些化合物对革兰氏阳性细菌枯草杆菌显示出中等活性。
• Efficient Conversion of Tertiary Propargylamides into Imidazoles via Hydroamination–Cyclization
  作者：Mikhail Krasavin、Alexander Safrygin、Elena Krivosheyeva、Dmitry Dar’in

  DOI：10.1055/s-0036-1591599

  日期：2018.8

  A method to convert tertiary N-propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to N-propargyl lactams and tends to populate the so-called ‘lead-like’ chemistry space.

  报道了一种将三级N-丙炔胺转化为1,2,4-三取代咪唑的方法，该方法使用氯化铵和三氟乙酸锌作为催化剂。该方法方便、实用，并采用传统加热。它也适用于N-丙炔内酰胺，并倾向于填充所谓的“类铅”化学空间。
• Broad-Spectrum Radical Cyclizations Boosted by Polarity Matching. Carbonylative Access to α-Stannylmethylene Lactams from Azaenynes and CO
  作者：Ilhyong Ryu、Hironari Miyazato、Hiroki Kuriyama、Kazutoshi Matsu、Mami Tojino、Takahide Fukuyama、Satoshi Minakata、Mitsuo Komatsu

  DOI：10.1021/ja034896u

  日期：2003.5.1

  Free-radical mediated stannylcarbonylation of azaenynes provides a general [n + 1]-type annulation approach leading to alpha-stannylmethylene lactams. The cyclization is unusual in its breadth, covering 4-exo, 5-exo, 6-exo, 7-exo, and 8-exo modes.
• An expeditious and atom-economic synthesis of lead-like, medicinally important 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones
  作者：Prashant Mujumdar、Alexander Sapegin、Mikhail Dorogov、Mikhail Krasavin

  DOI：10.1016/j.tetlet.2014.06.104

  日期：2014.10

  We have developed an expeditious and atom-economic synthesis of lead-like, privileged 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones, which is based on Sonogashira coupling and a two-step condensation with hydrazine hydrate leading to two ring-forming events, with full control over the two elements of diversity present. (C) 2014 Published by Elsevier Ltd.