(2Z)-1-(2-furyl)-2-phenyl-2-nonene-1,4-dione | 888224-92-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2Z)-1-(2-furyl)-2-phenyl-2-nonene-1,4-dione
• CAS: 888224-92-8
• 化学式: C₁₉H₂₀O₃
• 分子量: 296.366
• InChiKey: RCXYWJQAQPAFLY-VKAVYKQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  47.28
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2Z)-1-(2-furyl)-2-phenyl-2-nonene-1,4-dione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以96%的产率得到3-(2-furyl)-6-pentyl-4-phenylpyridazine
  参考文献：
  名称：

  Stereoselective Functionalization of β-Iodo-α,β-Unsaturated Ketones via an Iodine−Copper Exchange Reaction

  摘要：

  beta-lodo-alpha,beta-unsaturated carbonyl compounds undergo a stereoselective iodine-copper exchange reaction with (Nphyl)(2)CuLi, providing the corresponding alkenyl cuprates with retention of the double bond configuration. No competitive addition/elimination was observed, and the resulting cuprates were successfully functionalized with various electrophiles.

  DOI：

  10.1021/ol060540m
• 作为产物：
  描述：

  (1Z)-1-iodo-1-phenyl-1-octen-3-one 在 lithium di(2,2-dimethyl-2-phenylethyl)cuprate 作用下， 以 四氢呋喃 为溶剂， 反应 1.33h， 生成 (2Z)-1-(2-furyl)-2-phenyl-2-nonene-1,4-dione
  参考文献：
  名称：

  Stereoselective Functionalization of β-Iodo-α,β-Unsaturated Ketones via an Iodine−Copper Exchange Reaction

  摘要：

  beta-lodo-alpha,beta-unsaturated carbonyl compounds undergo a stereoselective iodine-copper exchange reaction with (Nphyl)(2)CuLi, providing the corresponding alkenyl cuprates with retention of the double bond configuration. No competitive addition/elimination was observed, and the resulting cuprates were successfully functionalized with various electrophiles.

  DOI：

  10.1021/ol060540m