Fucoxanthinol | 7176-02-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Fucoxanthinol
• CAS: 7176-02-5
• 化学式: C₄₀H₅₆O₅
• 分子量: 616.882
• InChiKey: NZEPSBGUXWWWSI-FWFPOGQTSA-N

物化性质

• 熔点：
  146-148 °C
• 沸点：
  762.8±60.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  90.3
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  fucoxanthin 在 水 、 lipase 作用下， 生成 Fucoxanthinol
  参考文献：
  名称：

  Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites

  摘要：

  Antioxidant activity of carotenoids is suggested to be one of the factors; for their disease preventing effects. Marine carotenoids fucoxanthin and its two metabolites, fucoxanthinol and halocynthiaxanthin, have been shown to exhibit several biological effects. The antioxidant activities of these three carotenoids were assessed in vitro with respect to radical scavenging and singlet oxygen quenching abilities. The 1,1 -diphenyl-2-picrylhydrazyl radical scavenging activity of fucoxanthin and fucoxanthinol was higher than that of halocynthiaxanthin, with the effective concentration for 50% scavenging (EC50) being 164.60, 153.78, and 826.39 mu M, respectively. 2,2'-Azinobis-3-ethylbenzo thizol ine-6-su I phonate radical scavenging activity of fucoxanthinol (EC50, 2.49 mu M) was stronger than that of fucoxanthin (EC50, 8.94 mu M). Hydroxyl radical scavenging activity as measured by the chemiluminescence technique showed that the scavenging activity of fucoxanthin was 7.9 times higher than that by fucoxanthinol, 16.3 times higher than that by halocynthiaxanthin, and 13.5 times higher than that by (x-tocopherol. A similar trend was observed when the hydroxyl radical scavenging was assessed by the electron spin resonance (ESR) technique. ESR analysis of the Superoxide radical scavenging activity also showed the superiority of fucoxanthin over the other two carotenoids tested. Singlet oxygen quenching ability of the three carotenoids was lower than that of beta-carotene, with quenching rate constants (k(Q), x 10(10) M-1 s(-1)) being 1.19, 1.81, 0.80, and 12.78 for fucoxanthin, fucoxanthinol, halocynthiaxanthin, and beta-carotene, respectively. The higher radical scavenging activity of fucoxanthin and fucoxanthinol compared with halocynthiaxanthin is assumed to be due to presence of the allenic bond.

  DOI：

  10.1021/jf071848a

文献信息

• INTERNAL COMPOSITION
  申请人：LION CORPORATION

  公开号：US20160067203A1

  公开（公告）日：2016-03-10

  An object of the present invention is to provide an internal composition capable of exerting various physiological functions such as a brain-function improving function. That is, the present invention provides an internal composition including docosahexaenoic acid and capsanthin, or docosahexaenoic acid, capsanthin, lutein, and zeaxanthin as active ingredients.

  本发明的一个目的是提供一种内部组合物，能够发挥各种生理功能，如改善脑功能。也就是说，本发明提供了一种包括二十二碳六烯酸和辣椒红素，或者二十二碳六烯酸、辣椒红素、叶黄素和玉米黄质作为活性成分的内部组合物。
• US9480672B2
  申请人：——

  公开号：US9480672B2

  公开（公告）日：2016-11-01