(13Z)-6β,7β-carbonyldioxy-15-tert-butyldimethylsilyloxy-labda-8,13-diene | 1061674-84-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (13Z)-6β,7β-carbonyldioxy-15-tert-butyldimethylsilyloxy-labda-8,13-diene
• CAS: 1061674-84-7
• 化学式: C₂₇H₄₆O₄Si
• 分子量: 462.745
• InChiKey: YVYAISQSUZFCTL-OEEAWWJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  32.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (13Z)-6β,7β-carbonyldioxy-15-tert-butyldimethylsilyloxy-labda-8,13-diene 、 四丁基醋酸铵 以 甲苯 为溶剂， 反应 46.0h， 以56%的产率得到(13Z)-7α-acetoxy-labda-8,13-diene-6β,15-diol
  参考文献：
  名称：

  Synthetic studies to highly functionalised B ring labdanes

  摘要：

  Several 6,7-dioxygenated (cis or trans) labdanes have been synthesised starting front sclareol. A new strategy that allows the obtention of diols alpha-cis as well as beta-cis of trans is described. In particular, the syntheses of three natural highly functionalised labdanes in the B rings of 2, 3 and 4 with different side chains are reported. The syntheses have permitted to Correct the proposed Structure for one of them. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.083
• 作为产物：
  描述：

  三光气 、 (13Z)-15-tert-butyldimethylsilyloxy-labda-8,13-diene-6β,7β-diol 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到(13Z)-6β,7β-carbonyldioxy-15-tert-butyldimethylsilyloxy-labda-8,13-diene
  参考文献：
  名称：

  Synthetic studies to highly functionalised B ring labdanes

  摘要：

  Several 6,7-dioxygenated (cis or trans) labdanes have been synthesised starting front sclareol. A new strategy that allows the obtention of diols alpha-cis as well as beta-cis of trans is described. In particular, the syntheses of three natural highly functionalised labdanes in the B rings of 2, 3 and 4 with different side chains are reported. The syntheses have permitted to Correct the proposed Structure for one of them. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.083