3-chloro-6-(4-chloro-2,6-dimethylphenoxy)pyridazine | 1184209-35-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-chloro-6-(4-chloro-2,6-dimethylphenoxy)pyridazine
• CAS: 1184209-35-5
• 化学式: C₁₂H₁₀Cl₂N₂O
• 分子量: 269.13
• InChiKey: DMBZSETWHFBIJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-chloro-6-(4-chloro-2,6-dimethylphenoxy)pyridazine 在 溶剂黄146 作用下， 反应 6.0h， 以97%的产率得到6-(4-chloro-2,6-dimethylphenoxy)pyridazin-3(2H)-one
  参考文献：
  名称：

  Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)

  摘要：

  In this Letter, we report on diarylpyridinone, diarylpyridazinone and diarylphthalazinone analogs as potential inhibitors of HIV-1 nonnucleoside reverse transcriptase (NNRTIs). The most promising compounds in these series are three diarylpyridazinones 25a, 25I and 25n which demonstrated submicromolar activity against wild-type HIV-1 and moderate activity against the single mutant strain Ba-L V106A. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.08.060
• 作为产物：
  描述：

  3,6-二氯哒嗪 、 4-氯-2,6-二甲基苯酚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以71%的产率得到3-chloro-6-(4-chloro-2,6-dimethylphenoxy)pyridazine
  参考文献：
  名称：

  Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)

  摘要：

  In this Letter, we report on diarylpyridinone, diarylpyridazinone and diarylphthalazinone analogs as potential inhibitors of HIV-1 nonnucleoside reverse transcriptase (NNRTIs). The most promising compounds in these series are three diarylpyridazinones 25a, 25I and 25n which demonstrated submicromolar activity against wild-type HIV-1 and moderate activity against the single mutant strain Ba-L V106A. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.08.060