4-硝基-1-苯基-1,2-二氢吡唑-3-酮 | 7409-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-硝基-1-苯基-1,2-二氢吡唑-3-酮
• 英文名称: 4-nitro-1-phenyl-1,2-dihydro-pyrazol-3-one
• 英文别名: 4-Nitro-1-phenyl-1,2-dihydro-pyrazol-3-on；4-nitro-2-phenyl-1H-pyrazol-5-one
• CAS: 7409-22-5
• 化学式: C₉H₇N₃O₃
• 分子量: 205.173
• InChiKey: MSJYBAMJVMALRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-硝基-1-苯基-1,2-二氢吡唑-3-酮 在 palladium on activated charcoal 氢气 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-苯基-4-苯基乙酰氨-3-吡唑烷-5酮
  参考文献：
  名称：

  Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors

  摘要：

  A new series of potential human 5-LOX inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 2) has been synthesized and the activity against COX-1, COX-2, and human 5-LOX enzymes has been evaluated. In contrast with literature data, we observed that phenidone resulted to be inactive against human 5-LOX, while retains its activity against cyclooxygenases in a micromolar range. The present results suggest that the substitution of the amino function at the 4-position is detrimental in terms of activity toward COX-1 and COX-2, while the presence of a double bond at the 4,5-position does not alter the biological profile against COX. The absence of activity vs. human 5-LOX strongly suggests a re-consideration of phenidone and its analogs as 5-LOX inhibitors in humans.

  DOI：

  10.1016/j.farmac.2004.09.002
• 作为产物：
  描述：

  1-苯基-1,5-二氢-4H-咪唑-4-酮 在 硝酸 作用下， 生成 4-硝基-1-苯基-1,2-二氢吡唑-3-酮
  参考文献：
  名称：

  Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors

  摘要：

  A new series of potential human 5-LOX inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 2) has been synthesized and the activity against COX-1, COX-2, and human 5-LOX enzymes has been evaluated. In contrast with literature data, we observed that phenidone resulted to be inactive against human 5-LOX, while retains its activity against cyclooxygenases in a micromolar range. The present results suggest that the substitution of the amino function at the 4-position is detrimental in terms of activity toward COX-1 and COX-2, while the presence of a double bond at the 4,5-position does not alter the biological profile against COX. The absence of activity vs. human 5-LOX strongly suggests a re-consideration of phenidone and its analogs as 5-LOX inhibitors in humans.

  DOI：

  10.1016/j.farmac.2004.09.002

文献信息

• Interlocking Trajectories of Loss-Related Events and Depressive Symptoms Among Elders
  作者：S. M. Lynch、L. K. George

  DOI：10.1093/geronb/57.2.s117

  日期：2002.3.1

  Objectives. As people age, their peers (who are also aging) become increasingly susceptible to health decline and death, implying potential growth in stressful loss-related events over time for the individual. Yet little research has examined trajectories of stress and their relationship to trajectories of depression among elders. The purpose of this research was to determine whether growth in loss-related events occurs for elders and whether stress growth is related to the well-known growth in depressive symptomatology in later life.Methods. Three waves of National Institute on Aging Established Populations for Epidemiologic Studies of the Elderly (Duke University site) data were used in the analyses. Latent growth curve models were estimated for stress. for depressive symptoms, and for stress predicting depression net of several covariates.Results. Findings include that (a) loss-events evidence clear growth across age at the aggregate level, but with Much variation within the sample, and (b) variation in growth in stress is strongly related to variation in growth in depressive symptoms.Discussion. The results suggest that stress in later life may be conceived of as a growth process, with strong consequences for trajectories of mental health.
• Kuemmell; Remy, Zeitschrift fur Elektrochemie und angewandte physikalische Chemie, 1909, vol. 15, p. 254
  作者：Kuemmell、Remy

  DOI：——

  日期：——
• Remy, Diss. <Rostock 1909>, S. 27
  作者：Remy

  DOI：——

  日期：——