4-methyl-2-(4-fluorobenzenesulfonyl)quinoline-N-oxide | 1426249-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methyl-2-(4-fluorobenzenesulfonyl)quinoline-N-oxide
• 英文别名: 2-(4-Fluorophenyl)sulfonyl-4-methyl-1-oxidoquinolin-1-ium；2-(4-fluorophenyl)sulfonyl-4-methyl-1-oxidoquinolin-1-ium
• CAS: 1426249-91-3
• 化学式: C₁₆H₁₂FNO₃S
• 分子量: 317.341
• InChiKey: JQZISPRDEJMQSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲基喹啉 在 copper(l) iodide 、 双氧水 、 potassium carbonate 作用下， 以 溶剂黄146 为溶剂， 反应 96.0h， 生成 4-methyl-2-(4-fluorobenzenesulfonyl)quinoline-N-oxide
  参考文献：
  名称：

  Sulfonylation of Quinoline N-Oxides with Aryl Sulfonyl Chlorides via Copper-Catalyzed C–H Bonds Activation

  摘要：

  An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.

  DOI：

  10.1021/ol400178k

文献信息

• Sulfonylation of Quinoline <i>N</i>-Oxides with Aryl Sulfonyl Chlorides via Copper-Catalyzed C–H Bonds Activation
  作者：Zhiyong Wu、Hongyu Song、Xiuling Cui、Chao Pi、Weiwei Du、Yangjie Wu

  DOI：10.1021/ol400178k

  日期：2013.3.15

  An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.