6-methoxy-4-methyl-8-nitro-2-vinylquinoline | 73321-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-4-methyl-8-nitro-2-vinylquinoline
• 英文别名: 2-Ethenyl-6-methoxy-4-methyl-8-nitroquinoline
• CAS: 73321-82-1
• 化学式: C₁₃H₁₂N₂O₃
• 分子量: 244.25
• InChiKey: ONAHFCFHQHQVGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methoxy-4-methyl-8-nitro-2-vinylquinoline 在 镍 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 60.0~125.0 ℃ 、275.79 kPa 条件下， 反应 27.0h， 生成 8-<<6'-(diethylamino)hexyl>amino>-2-ethyl-6-methoxy-4-methylquinoline
  参考文献：
  名称：

  Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics

  摘要：

  A series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against Plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.

  DOI：

  10.1021/jm00179a023
• 作为产物：
  描述：

  6-methoxy-4-methyl-8-nitro-2-<β-(trimethylamino)ethyl>quinolinium iodide 在 sodium hydroxide 作用下， 以 氯仿 为溶剂， 以87%的产率得到6-methoxy-4-methyl-8-nitro-2-vinylquinoline
  参考文献：
  名称：

  Synthesis of 2,4-disubstituted 6-methoxy-8-aminoquinoline analogs as potential antiparasitics

  摘要：

  A series of 2,4-disubstituted 8-aminoquinoline analogues were synthesized and evaluated against Plasmodium berghei in mice and Leishmania donovani in hamsters. 8-[[6-(Diethylamino)hexyl]amino]-2-ethyl-6-methoxy-4-methylquinoline (8a) possessed significant activity against L. donovani. 2-Ethyl-4-methylprimaquine (7a) was evaluated against Plasmodium cynomolgi in rhesus monkey and found to have activity equal to that of primaquine.

  DOI：

  10.1021/jm00179a023

文献信息

• CORROLLY F. I.; BERRANG B. D.; LINN C. P., J. MED. CHEM., 1980, 23, NO 5, 581-584
  作者：CORROLLY F. I.、 BERRANG B. D.、 LINN C. P.

  DOI：——

  日期：——