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2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose | 1254044-54-6

中文名称
——
中文别名
——
英文名称
2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose
英文别名
——
2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose化学式
CAS
1254044-54-6
化学式
C75H80Cl3NO19
mdl
——
分子量
1405.81
InChiKey
OASMUTQXLWKLEH-YLHBFQOMSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    11.2
  • 重原子数:
    98.0
  • 可旋转键数:
    32.0
  • 环数:
    10.0
  • sp3杂化的碳原子比例:
    0.39
  • 拓扑面积:
    218.76
  • 氢给体数:
    1.0
  • 氢受体数:
    19.0

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose偶氮二异丁腈三正丁基氢锡 作用下, 以 为溶剂, 反应 1.0h, 以70%的产率得到2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose
    参考文献:
    名称:
    Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens
    摘要:
    Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.
    DOI:
    10.1021/bc100288c
  • 作为产物:
    描述:
    benzyl O-(2,3,6-tri-O-benzyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzyl-β-D-glucopyranosidephenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-trichloroacetamido-β-D-galactopyranosideN-碘代丁二酰亚胺三氟甲磺酸 作用下, 以 二氯甲烷 为溶剂, 反应 4.5h, 以84%的产率得到2-deoxy-3,4,6-tri-O-acetyl-2-trichloroacetamido-β-D-galactopyranosyl-(1->4)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1->4)-1,2,3,6-tetra-O-benzyl-D-glucopyranose
    参考文献:
    名称:
    Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens
    摘要:
    Bishydrazides are versatile linkers for attaching glycans to substrates for lectin binding and pathogen detection schemes. The alpha,omega-bishydrazides of carboxymethylated hexa(ethylene glycol) (4) can be conjugated at one end to unprotected oligosaccharides, then attached onto carrier proteins, tethered onto activated carboxyl-terminated surfaces, or functionalized with a photoactive cross-linking agent for lithographic patterning. Glycoconjugates of bishydrazide 4 can also be converted into dithiocarbamates (DTCs) by treatment with CS2 under mild conditions, for attachment onto gold substrates. The immobilized glycans serve as recognition elements for cell-surface lectins and enable the detection and capture of bacterial pathogens such as Pseudomonas aeruginosa by their adsorption onto micropatterned substrates. A detection limit of 10(3) cfu/mL is demonstrated, using a recently introduced method based on optical pattern recognition.
    DOI:
    10.1021/bc100288c
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