| 1224442-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1224442-68-5
• 化学式: C₂₂H₁₆N₂
• 分子量: 308.382
• InChiKey: SPAQJEVVVRQUQT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 丙烯酸甲酯（MA） 在 copper diacetate 、 palladium diacetate 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 以16%的产率得到
  参考文献：
  名称：

  Observation of 2,7-Disubstitution in Palladium Catalysed Directed C-H Activation of Indoles

  摘要：

  In previous work, controlled C-H activation and catalytic Heck reaction at the 2-position of indole was demonstrated. This was achieved by means of a N-(2-pyridylmethyl) directing group. In the course of extending the initial observations it was discovered that the corresponding N-(1-isoquinolylmethyl)indole derivative was prone to a further oxidative Heck reaction giving rise to a 2,7-disubstituted product, which was characterised by NMR and X-ray analysis. The parent pyridine showed no tendency for a second substitution reaction at the indole 7-position, but the related N-(2-quinolylmethyl) derivative did. In the case of the corresponding 6-methylphenanthridinyl derivative, a novel oxidative C-C cleavage reaction was observed.

  DOI：

  10.3987/com-09-s(s)117