(Z)-3-chloro-3-(3,4-dimethoxyphenyl)acrylic acid | 1258494-04-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-3-chloro-3-(3,4-dimethoxyphenyl)acrylic acid
• 英文别名: (Z)-3-chloro-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
• CAS: 1258494-04-0
• 化学式: C₁₁H₁₁ClO₄
• 分子量: 242.659
• InChiKey: DHYAXEYFJNMBCW-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-3-氯-3-(3,4-二甲氧基苯基)丙烯醛 在 sodium chlorite 、 sodium phosphate dibasic dodecahydrate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 24.0h， 以92%的产率得到(Z)-3-chloro-3-(3,4-dimethoxyphenyl)acrylic acid
  参考文献：
  名称：

  The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones

  摘要：

  Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic acids are described The successful strategy relies on the preparation of (Z)-3-aryl-3-haloenoic acids from acetophenones through the corresponding (Z)-3-aryl-3-haloenals and the conversion of the (Z)-3-aryl-3-haloenoic acids to (Z)-5-benzylidene-4-aryl-5H-furan-2-ones The furanones were subsequently treated with primary amines and dehydrated to the corresponding (Z)-5-benzylidene-4-arylpyrrol-2(5H)-one (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.09.080

文献信息

• The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones
  作者：John T. Gupton、Nakul Telang、Edith J. Banner、Emily J. Kluball、Kayleigh E. Hall、Kara L. Finzel、Xin Jia、Spencer R. Bates、R. Scott Welden、Benjamin C. Giglio、James E. Eaton、Peter J. Barelli、Lauren T. Firich、John A. Stafford、Matthew B. Coppock、Eric F. Worrall、Rene P.F. Kanters、Kerry Keertikar、Rebecca Osterman

  DOI：10.1016/j.tet.2010.09.080

  日期：2010.11

  Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic acids are described The successful strategy relies on the preparation of (Z)-3-aryl-3-haloenoic acids from acetophenones through the corresponding (Z)-3-aryl-3-haloenals and the conversion of the (Z)-3-aryl-3-haloenoic acids to (Z)-5-benzylidene-4-aryl-5H-furan-2-ones The furanones were subsequently treated with primary amines and dehydrated to the corresponding (Z)-5-benzylidene-4-arylpyrrol-2(5H)-one (C) 2010 Elsevier Ltd All rights reserved