5-[4-(2,3-dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)-pentylamino]quinolin-2(1H)-one | 887375-33-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-[4-(2,3-dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)-pentylamino]quinolin-2(1H)-one
• 英文别名: 5-[4-(2,3-Dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]quinolin-2[1H]-one；5-[[4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]-1H-quinolin-2-one
• CAS: 887375-33-9
• 化学式: C₂₄H₂₄F₄N₂O₃
• 分子量: 464.46
• InChiKey: WDUDKUGGIMDQAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.6
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  、 4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal 、 5-氨基-2-氧代-1,2-二氢喹啉 、 氰基硼氢化钠 生成 5-[4-(2,3-dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)-pentylamino]quinolin-2(1H)-one
  参考文献：
  名称：

  5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents

  摘要：

  通式为(IIa)或(IIb)的化合物及其作为药物代理的用途。

  公开号：

  US07417056B2

文献信息

• 5-Substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
  申请人：Jaroch Stefan

  公开号：US20060116396A1

  公开（公告）日：2006-06-01

  Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.

  通式为（IIa）或（IIb）的化合物及其作为药物的用途。
• COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING INFLAMMATORY PAIN
  申请人：Ward Keith W.

  公开号：US20120316199A1

  公开（公告）日：2012-12-13

  A composition for treating, controlling, reducing, or ameliorating inflammatory pain comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. It may be used in a method of managing post-surgical ocular pain such that it has lower risk of eliciting adverse side effects seen with other therapeutic agents.

  用于治疗、控制、减轻或改善炎症性疼痛的组合物包括解离型糖皮质激素受体激动剂（“DIGRA”）、其前药、其药学上可接受的盐或其药学上可接受的酯。该组合物可以包含额外的抗炎药物，并可制成局部应用、注射或植入剂。它可以用于管理术后眼部疼痛的方法，从而降低与其他治疗剂产生的不良副作用风险。
• Compositions and methods for treating or preventing glaucoma or progression thereof
  申请人：BAUSCH & LOMB INCORPORATED

  公开号：EP2397140A1

  公开（公告）日：2011-12-21

  A composition for treating or preventing glaucoma or its progression comprises a dissociated glucocorticoid receptor agonist ("DIGRA"), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. It may be used in combination with another therapy directed to reducing intraocular pressure.

  一种用于治疗或预防青光眼或青光眼进展的组合物包含一种离体糖皮质激素受体激动剂（"DIGRA"）、其原药、其药学上可接受的盐或其药学上可接受的酯。该组合物可包含一种额外的抗炎剂，并可配制成外用、注射或植入剂。它可与另一种降低眼内压的疗法联合使用。
• 5-SUBSTITUIERTE CHINOLIN- UND ISOCHINOLIN-DERIVATE; EIN VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ENTZÜNDUNGSHEMMER
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1844039B1

  公开（公告）日：2009-07-15
• TREATING INFECTIONS AND SEQUELAE THEREOF WITH COMBINED DISSOCIATED GLUCOCORTICOID RECEPTOR AGONISTS AND ANTI-INFECTIVE AGENTS
  申请人：Bausch & Lomb Incorporated

  公开号：EP2049112B1

  公开（公告）日：2012-03-14