N-(3-diethoxyphosphorylpropylidene)hydroxylamine | 688810-48-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: N-(3-diethoxyphosphorylpropylidene)hydroxylamine
• CAS: 688810-48-2
• 化学式: C₇H₁₆NO₄P
• 分子量: 209.182
• InChiKey: QYTOXOOOILFHMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  68.12
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N-(3-diethoxyphosphorylpropylidene)hydroxylamine 在 吡啶 、 N-氯代丁二酰亚胺 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 [2-(4,6-Dioxo-5-phenyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazol-3-yl)-ethyl]-phosphonic acid diethyl ester
  参考文献：
  名称：

  One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells

  摘要：

  1,3 Dipolar cycloadditions of nitrile oxides generated in situ in the presence of a variety of olefins provided 4,5-dihydroisoxazoles. The whole procedure could be performed in a practical and efficient one-pot operation. The products are of excellent purity (95%) and are isolated in 60-83% yields. Some of them enhanced the accumulation of indole alkaloids in periwinkle cell cultures. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.008
• 作为产物：
  描述：

  diethyl (3-oxopropyl)phosphonate 在 羟胺 、 碳酸氢钠 作用下， 以 乙醇 、 水 为溶剂， 以65%的产率得到N-(3-diethoxyphosphorylpropylidene)hydroxylamine
  参考文献：
  名称：

  One-pot synthesis of functionalized 4,5-dihydroisoxazole derivatives via nitrile oxides and biological evaluation with plant cells

  摘要：

  1,3 Dipolar cycloadditions of nitrile oxides generated in situ in the presence of a variety of olefins provided 4,5-dihydroisoxazoles. The whole procedure could be performed in a practical and efficient one-pot operation. The products are of excellent purity (95%) and are isolated in 60-83% yields. Some of them enhanced the accumulation of indole alkaloids in periwinkle cell cultures. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.008