[{2-[acridine-9-carboxamide]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid methyl ester | 1029684-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [{2-[acridine-9-carboxamide]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid methyl ester
• CAS: 1029684-05-6
• 化学式: C₂₆H₃₀N₄O₆
• 分子量: 494.547
• InChiKey: AYNSHMWCXFLBQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.64
• 重原子数：
  36.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  126.93
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  [{2-[acridine-9-carboxamide]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid methyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以34%的产率得到[{2-[acridine-9-carbonylamino]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid
  参考文献：
  名称：

  Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones

  摘要：

  The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.045
• 作为产物：
  描述：

  2-(acridine-9-carboxamide)acetic acid 、 methyl N-(2-(tert-butyloxycarbonyl)aminoethyl)glycinate 在 N-乙基吗啉 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以40%的产率得到[{2-[acridine-9-carboxamide]-acetyl}-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid methyl ester
  参考文献：
  名称：

  Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones

  摘要：

  The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.045