3,3,6,6-tetramethyl-9-(2-(4-(2-(3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dion-9-yl)phenoxy)butoxy)phenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione | 1190108-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,3,6,6-tetramethyl-9-(2-(4-(2-(3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dion-9-yl)phenoxy)butoxy)phenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione
• 英文别名: 9,9'-{2,2'-[butane-1,4-diylbis(oxy)]bis(1,2-phenylene)}bis[3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione]
• CAS: 1190108-64-5
• 化学式: C₅₀H₆₀N₂O₆
• 分子量: 785.036
• InChiKey: VDCCVEXEKPUNSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.87
• 重原子数：
  58.0
• 可旋转键数：
  9.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  110.8
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 ((butane-1,4-diylbis(oxy))bis(2,1-phenylene))dimethanol 在 aluminum hydrogen sulfate 、 ammonium acetate 、 sodium bromide 、 sodium nitrite 作用下， 以 neat (no solvent) 为溶剂， 反应 0.83h， 以89%的产率得到3,3,6,6-tetramethyl-9-(2-(4-(2-(3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dion-9-yl)phenoxy)butoxy)phenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione
  参考文献：
  名称：

  Benzyl alcohol-based synthesis of mono- and bis-dihydropyridines in the presence of Al(HSO4)3, sodium nitrite, and sodium bromide under solvent-free conditions

  摘要：

  Dihydropyridines were synthesized in good to excellent yields in the presence of NaNO2, Al(HSO4)(3), and a catalytic amount of NaBr at room temperature. Low cost, the use of available reagents, simple methodology, and easy work-up procedure make this method attractive for organic synthesis.

  DOI：

  10.1134/s1070363216060281

文献信息

• An Efficient One-Pot Three-Component Synthesis of Fused 1,4-Dihydropyridines Using HY-Zeolit
  作者：Mohammad Nikpassand、Manouchehr Mamaghani、Khalil Tabatabaeian

  DOI：10.3390/molecules14041468

  日期：——

  A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90%) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.

  开发了一种简便的方案，用于在 HY-沸石作为一种有效的可回收多相催化剂的存在下，从二甲酮中快速 (2.5-3.5 h) 和高产率 (70-90%) 合成稠合 1,4-二氢吡啶。