| 464189-99-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 464189-99-9
• 化学式: C₈₉H₉₄N₂O₁₉Si
• 分子量: 1523.81
• InChiKey: IPLTYTRWDPQMRV-OOIVBBEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.02
• 重原子数：
  111.0
• 可旋转键数：
  28.0
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  221.05
• 氢给体数：
  0.0
• 氢受体数：
  19.0

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 氢氟酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、999.99 MPa 条件下， 以88%的产率得到C₇₃H₇₆N₂O₁₉
  参考文献：
  名称：

  Desilylation under high pressure

  摘要：

  Cleavage of tert-butyldiphenylsilyl (TBDPS) ether was examined under high pressure conditions (1.0 GPa) using HF pyridine in DMF. This method proved to be exceptionally suitable for deprotecting the TBDPS group that resides at the sterically hindered position. Under these conditions, various types of other hydroxyl protecting groups (i.e. benzyl, p-methoxybenzyl, trityl, isopropylidene, cyclohexylidene, allyl, phthaloyl) as well as O- and S-glycosidic linkages were preserved. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00538-5
• 作为产物：
  描述：

  allyl-3,6-di-O-benzyl-2-deoxy-2-N-phthalimido-β-D-glucopyranoside 、 [(4aR,6S,7S,8S,8aR)-8-[tert-butyl(diphenyl)silyl]oxy-6-[(2R,3S,4R,5R,6S)-5-(1,3-dioxoisoindol-2-yl)-6-fluoro-4-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl]oxyspiro[4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-2,1'-cyclohexane]-7-yl] acetate 在 二氯二茂铪 、 4 A molecular sieve 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到
  参考文献：
  名称：

  Synthesis of Monoglucosylated High-Mannose-Type Dodecasaccharide, a Putative Ligand for Molecular Chaperone, Calnexin, and Calreticurin

  摘要：

  Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), alpha-Glc1M9GlcNAc2 (2b), and its stereoisomer beta-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

  DOI：

  10.1021/ja021288q

文献信息

• Tight binding ligand approach to oligosaccharide-grafted protein
  作者：Kiichiro Totani、Ichiro Matsuo、Yukishige Ito

  DOI：10.1016/j.bmcl.2004.01.106

  日期：2004.5

  A novel type of artificial glycoprotein was developed, by using dihydrofolate reductase (DHFR) and methotrexate (MTX) as a protein-ligand pair. Various oligosaccharides linked to MTX were shown to bind tightly with DHFR and afforded oligosaccharide-grafted protein, which could be isolated easily by lectin beads. (C) 2004 Elsevier Ltd. All rights reserved.