-OH | 133472-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: -OH
• 英文别名: [G-2]-OH；4,4-Bis[4-[4,4-bis(4-phenylmethoxyphenyl)pentoxy]phenyl]pentan-1-ol
• CAS: 133472-85-2
• 化学式: C₇₉H₈₀O₇
• 分子量: 1141.5
• InChiKey: CKTFERZGPQNTHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.4
• 重原子数：
  86
• 可旋转键数：
  31
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  -OH 在 四溴化碳 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以92%的产率得到-Br
  参考文献：
  名称：

  Hyperbranched macromolecules via a novel double-stage convergent growth approach

  摘要：

  A novel double-stage convergent growth approach for the preparation of dendritic macromolecules is described. In the first stage, convergent growth with 4,4-bis(4'-hydroxyphenyl)pentanol as the building block is used to create symmetrical dendritic structures containing a large number of phenolic ''surface'' functionalities. In the second stage of growth, these polyphenolic dendritic macromolecules are utilized as cores for the attachment of other dendritic macromolecules, derived from 3,5-dihydroxybenzyl alcohol, that contain a single benzylic bromide reactive group at their focal point. This two-stage process affords hyperbranched spherical macromolecules consisting of a flexible inner core surrounded by a more rigid outer layer. The double-stage convergent growth approach allows for the preparation of larger dendrimers in less time and with greater ease than the single-stage approach while retaining the advantages of near monodispersity and ease of purification and characterization.

  DOI：

  10.1021/ja00011a031
• 作为产物：
  描述：

  4-hydroxy-γ-(4-hydroxyphenyl)-γ-methyl-benzenebutanoic acid methyl ester 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 62.0h， 生成 -OH
  参考文献：
  名称：

  Synthesis of a Series of Focally-Substituted Organothiol Dendrons

  摘要：

  The synthesis of new organothiol-functionalized dendrons of generation 1-4 is described. Several modifications to the original method for preparation of dendrons are detailed that were found to improve the yield and aid in scale-up. A particularly advantageous method for preparation of an aromatic thiol is reported and is employed in this reaction sequence. Several uses of these dendrons are anticipated and briefly described.

  DOI：

  10.1021/jo961527q

文献信息

• Synthesis of a Series of Focally-Substituted Organothiol Dendrons
  作者：Kang-Yi Chen、Christopher B. Gorman

  DOI：10.1021/jo961527q

  日期：1996.1.1

  The synthesis of new organothiol-functionalized dendrons of generation 1-4 is described. Several modifications to the original method for preparation of dendrons are detailed that were found to improve the yield and aid in scale-up. A particularly advantageous method for preparation of an aromatic thiol is reported and is employed in this reaction sequence. Several uses of these dendrons are anticipated and briefly described.
• Hyperbranched macromolecules via a novel double-stage convergent growth approach
  作者：Karen L. Wooley、Craig J. Hawker、J. M. J. Frechet

  DOI：10.1021/ja00011a031

  日期：1991.5

  A novel double-stage convergent growth approach for the preparation of dendritic macromolecules is described. In the first stage, convergent growth with 4,4-bis(4'-hydroxyphenyl)pentanol as the building block is used to create symmetrical dendritic structures containing a large number of phenolic ''surface'' functionalities. In the second stage of growth, these polyphenolic dendritic macromolecules are utilized as cores for the attachment of other dendritic macromolecules, derived from 3,5-dihydroxybenzyl alcohol, that contain a single benzylic bromide reactive group at their focal point. This two-stage process affords hyperbranched spherical macromolecules consisting of a flexible inner core surrounded by a more rigid outer layer. The double-stage convergent growth approach allows for the preparation of larger dendrimers in less time and with greater ease than the single-stage approach while retaining the advantages of near monodispersity and ease of purification and characterization.