4-(4-bromophenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one | 1393686-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-bromophenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one
• CAS: 1393686-59-3
• 化学式: C₁₉H₁₄BrNO
• 分子量: 352.23
• InChiKey: SDANKCREGCBVTB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 1-萘胺 、 对溴苯甲醛 以 溶剂黄146 为溶剂， 反应 0.2h， 以87%的产率得到4-(4-bromophenyl)-3,4-dihydrobenzo[h]quinolin-2(1H)-one
  参考文献：
  名称：

  Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating

  摘要：

  A sequential three-component reaction of aromatic aldehydes with aromatic amine, and Meldrum's acid in EtOH under microwave irradiation has been developed. In this one-pot reaction, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized with high chemical yields. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.

  DOI：

  10.3987/com-12-12489