2-((2-Chloroquinolin-3-yl)methylene)hydrazinecarbothioamide | 1379537-74-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-((2-Chloroquinolin-3-yl)methylene)hydrazinecarbothioamide
• 英文别名: [(E)-(2-chloroquinolin-3-yl)methylideneamino]thiourea
• CAS: 1379537-74-2
• 化学式: C₁₁H₉ClN₄S
• 分子量: 264.738
• InChiKey: CGJGGSPYFVUYDS-MKMNVTDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((2-Chloroquinolin-3-yl)methylene)hydrazinecarbothioamide 、 乙酸酐 反应 1.0h， 以65%的产率得到N-(4-acetyl-5-(2-chloroquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-acetamide
  参考文献：
  名称：

  An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents

  摘要：

  A series of 6,7,8-substituted thiosemicarbazones (2a-j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a-j) using acetic anhydride. The structures of the final compounds (3a-j) were confirmed by elemental and spectral (IR, H-1 NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.

  DOI：

  10.1007/s00044-010-9522-z
• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 氨基硫脲 在 silica-modified imidazolium iron chloride functionalized graphene nano sheets 作用下， 以 neat (no solvent) 为溶剂， 反应 0.05h， 以96%的产率得到2-((2-Chloroquinolin-3-yl)methylene)hydrazinecarbothioamide
  参考文献：
  名称：

  Efficient reduction of graphene oxide to graphene nanosheets using a silica-based ionic liquid: synthesis, characterization and catalytic properties of IMD-Si/FeCl₄⁻@GNS

  摘要：

  离子液体修饰的石墨烯纳米片（IMD-Si/FeCl₄⁻@GNS）已被合成为合成（E）-选择性硫代半胱氨酮的高效催化剂。

  DOI：

  10.1039/c9nj05768d

文献信息

• Efficient reduction of graphene oxide to graphene nanosheets using a silica-based ionic liquid: synthesis, characterization and catalytic properties of IMD-Si/FeCl₄⁻@GNS
  作者：Mohd Umar Khan、Shaheen Siddiqui、Waqas Ahmad Khan、Zeba N. Siddiqui

  DOI：10.1039/c9nj05768d

  日期：——

  Ionic liquid-modified graphene nanosheets (IMD-Si/FeCl₄⁻@GNS) have been synthesized as efficient catalysts for the synthesis of (E)-selective thiosemicarbazones.

  离子液体修饰的石墨烯纳米片（IMD-Si/FeCl₄⁻@GNS）已被合成为合成（E）-选择性硫代半胱氨酮的高效催化剂。
• An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents
  作者：Sheetal B. Marganakop、Ravindra R. Kamble、Tasneem Taj、Mahadevappa Y. Kariduraganvar

  DOI：10.1007/s00044-010-9522-z

  日期：2012.2

  A series of 6,7,8-substituted thiosemicarbazones (2a-j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a-j) using acetic anhydride. The structures of the final compounds (3a-j) were confirmed by elemental and spectral (IR, H-1 NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.