diazidomalonyl | 188341-34-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diazidomalonyl
• 英文别名: malonyl azide；Malonylazid；propanedioyl diazide
• CAS: 188341-34-6
• 化学式: C₃H₂N₆O₂
• 分子量: 154.088
• InChiKey: CSCRHLFCGHLTNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diazidomalonyl 在 氯仿 作用下， 生成 亚甲基二异氰酸酯
  参考文献：
  名称：

  Methylene Diisocyanate¹

  摘要：

  DOI：

  10.1021/ja01150a530
• 作为产物：
  描述：

  丙二酰肼 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 diazidomalonyl
  参考文献：
  名称：

  [EN] FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
  [FR] SYNTHÈSE CHIMIQUE EN FLUX D'ISOCYANATES

  摘要：

  该披露提供了诸如流动化学等安全环保的方法，用于合成异氰酸酯，例如亚甲基二苯基二异氰酸酯、甲苯二异氰酸酯、己二胺二异氰酸酯、异佛尔酮二异氰酸酯和四甲基二异氰酸酯。

  公开号：

  WO2021119606A1

文献信息

• [EN] FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES<br/>[FR] SYNTHÈSE CHIMIQUE EN FLUX D'ISOCYANATES
  申请人：UNIV CALIFORNIA

  公开号：WO2021119606A1

  公开（公告）日：2021-06-17

  The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.

  该披露提供了诸如流动化学等安全环保的方法，用于合成异氰酸酯，例如亚甲基二苯基二异氰酸酯、甲苯二异氰酸酯、己二胺二异氰酸酯、异佛尔酮二异氰酸酯和四甲基二异氰酸酯。
• NOVEL FULLERENE CYCLOPROPANATION REACTION
  申请人：Zhang Jing

  公开号：US20110178316A1

  公开（公告）日：2011-07-21

  Fullerene compounds represented by the formulae Cm[C(R)CON3]n, Cm[C(R)NCO]n, Cm[C(R)NHCORd]n, and Cm[C(R)NH2]n, wherein Cm represents a fullerene moiety having m carbon atoms, m represents an even integer from about 60 to about 200, n represents an integer of about 1 or more, R represents an electron-withdrawing group, and Rd represents an alkoxy or alkylamino group. In addition, processes for preparing these fullerene compounds involving reacting an acyl azide with a fullerene in the presence of a base.

  本发明涉及一种以式Cm[C(R)CON3]n、Cm[C(R)NCO]n、Cm[C(R)NHCORd]n和Cm[C(R)NH2]n表示的富勒烯化合物，其中Cm表示具有m个碳原子的富勒烯基团，m表示从约60到约200的偶数整数，n表示约1或更多的整数，R表示电子吸引基团，Rd表示烷氧基或烷基氨基基团。此外，本发明还涉及制备这些富勒烯化合物的过程，包括在碱存在下将酰基叠氮化合物与富勒烯反应。
• Curtius, Journal fur praktische Chemie (Leipzig 1954), 1895, vol. <2>52, p. 225
  作者：Curtius

  DOI：——

  日期：——
• Synthesis of symmetrical pseudopeptides as potential inhibitors of the human immunodeficiency virus-1 protease
  作者：M Langlois、D Quintard、C Abalain

  DOI：10.1016/0223-5234(94)90025-6

  日期：1994.1

  It is demonstrated that HIV-1 protease is essential for the assembly and infectivity of the acquired immunodeficiency syndrome (AIDS) virus. This protease is an aspartyl protease with a 2-fold symmetry axis. Potential inhibitors were synthesized and consisted of a spacer linking 2 peptidic chains. They had to satisfy the following constraints: a C-2 symmetry axis, a backbone similar to the peptidic substrates, and side-chains filling the subsites S-n...S'(n). The compounds were synthesized via peptidic synthetic methods and evaluated in an enzymatic test with HIV-1 protease. Several compounds displayed an inhibitory activity at 10 mu M. They possessed the spacers CO, CO-CO, CO-CH2-CHOH-CO and the terminal chain Phe-O-iC(4)H(9). However, the structural-variation-based optimization of these different compounds failed and no potent inhibitors were prepared.
• Methylene Diisocyanate¹
  作者：Rhoda Roesch、Marvin H. Gold

  DOI：10.1021/ja01150a530

  日期：1951.6