2-benzyloxy-6-quinolinecarboxaldehyde | 300811-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-benzyloxy-6-quinolinecarboxaldehyde
• 英文别名: 2-Phenylmethoxyquinoline-6-carbaldehyde
• CAS: 300811-63-6
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: RYRFLLDSFIKCEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  磷,[(2-溴-1,4-亚苯基)二(亚甲基)]二[三苯基-,二溴化 、 2-benzyloxy-6-quinolinecarboxaldehyde 在 正丁基锂 作用下， 以 乙醇 、 正己烷 为溶剂， 以72%的产率得到
  参考文献：
  名称：

  Chiral Discrimination in Hydrogen-Bonded [7]Helicenes

  摘要：

  [GRAPHICS]A series of racemic [7]helicenes have been prepared and characterized both in solution and in the solid state. Despite the helicenes having the ability to self-assemble in a variety of stereochemical and topological relationships, they formed only enantiomerically pure dimers held together by two pairs of cooperative hydrogen bonds. The self-assembly process was enantiospecific in solution and diastereoselective in the crystal.

  DOI：

  10.1021/ol006366y
• 作为产物：
  描述：

  6-溴喹啉-2-酮 在 正丁基锂 、 silver carbonate 作用下， 以 四氢呋喃 、 正己烷 、 氯仿 为溶剂， 反应 49.0h， 生成 2-benzyloxy-6-quinolinecarboxaldehyde
  参考文献：
  名称：

  Chiral Discrimination in Hydrogen-Bonded [7]Helicenes

  摘要：

  [GRAPHICS]A series of racemic [7]helicenes have been prepared and characterized both in solution and in the solid state. Despite the helicenes having the ability to self-assemble in a variety of stereochemical and topological relationships, they formed only enantiomerically pure dimers held together by two pairs of cooperative hydrogen bonds. The self-assembly process was enantiospecific in solution and diastereoselective in the crystal.

  DOI：

  10.1021/ol006366y