4-cyclohexyl-2-methyl-1(3)H-imidazole | 117043-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-cyclohexyl-2-methyl-1(3)H-imidazole
• 英文别名: 4-Cyclohexyl-2-methyl-1(3)H-imidazol；4-cyclohexyl-2-methyl-1H-imidazole；5-cyclohexyl-2-methyl-1H-imidazole
• CAS: 117043-83-1
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: VORIEXQPIBRJLO-UHFFFAOYSA-N

物化性质

• 沸点：
  358.8±11.0 °C(Predicted)
• 密度：
  1.036±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-cyclohexyl-2-methyl-1(3)H-imidazole 在 正丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 (1-4-cyclohexyl-1-trityl-1H-imidazol-2-yl)butan-2-one
  参考文献：
  名称：

  A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability

  摘要：

  Following the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM) scaffold is described. Replacement of the ester moiety by thiazole ring significantly improved the metabolic stability while retaining antiviral activity against HIV-1 replication. These novel and potent DHPMs with bioisosteres could serve as advanced leads for further optimization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.133
• 作为产物：
  描述：

  2-chloro-1-cyclohexyl-1-ethanone 在 甲醇 、 potassium acetate 作用下， 生成 4-cyclohexyl-2-methyl-1(3)H-imidazole
  参考文献：
  名称：

  Schubert; Hofmann, Journal fur praktische Chemie (Leipzig 1954), 1959, vol. <4> 7, p. 119,130

  摘要：

  DOI：

文献信息

• FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF
  申请人：MEDIVATION TECHNOLOGIES, INC.

  公开号：US20160068513A1

  公开（公告）日：2016-03-10

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. Fused pyrimidine compounds that are inhibitors of Trk receptors (e.g., Trk A, Trk B and Trk C) are provided also. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.

  提供了作为激酶抑制剂的融合嘧啶化合物，例如多激酶抑制剂。提供了作为IGF-IR抑制剂的融合嘧啶化合物。还提供了抑制Trk受体（例如Trk A，Trk B和Trk C）的融合嘧啶化合物。这些化合物可以用于治疗癌症的方法。还提供了含有融合嘧啶化合物和药用载体的制药组合物，以及包含融合嘧啶化合物或其盐和使用说明的试剂盒，例如用于治疗癌症的方法。
• Iron-tetraphenylporphine complex having phosphocholine group and oxygen adsorbing and desorbing agent
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：EP0110396A2

  公开（公告）日：1984-06-13

  Disclosed is an iron-5,10,15,20-tetra(a,a,a,a,-o-substituted phenyl)porphine complex having one or four substituents with a phosphocholine group at the terminal end thereof. The substituents are positioned ortho of the phenyl group or groups. The complex is particularly useful as an oxygen adsorbing and desorbing agent.

  本发明公开了一种铁-5,10,15,20-四(a,a,a,a,-o-取代苯基)卟吩络合物，该络合物具有一个或四个取代基，其末端具有膦胆碱基团。取代基位于一个或多个苯基的正交位置。这种络合物尤其可用作氧气吸附剂和解吸附剂。
• [EN] ANTI VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：PASTEUR INSTITUT KOREA

  公开号：WO2010046780A3

  公开（公告）日：2011-01-13
• Purine Diones As Wnt Pathway Modulators
  申请人：Agency for Science, Technology and Research

  公开号：US20170334912A1

  公开（公告）日：2017-11-23

  The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R 1 , R 2 , R 3 , R 4 and R 5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
• US9499519B2
  申请人：——

  公开号：US9499519B2

  公开（公告）日：2016-11-22