ent-3α,15-dihydroxy-labda-8(17),13(E)-diene | 91925-68-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ent-3α,15-dihydroxy-labda-8(17),13(E)-diene
• 英文别名: 13(E)-ent-Labda-8(17),13-diene-3β,15-diol；(2R,4aS,5R,8aS)-5-[(E)-5-hydroxy-3-methylpent-3-enyl]-1,1,4a-trimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-2-ol
• CAS: 91925-68-7
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: VWLUMJKLKPQBCX-IGMVLXQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ent-15-hydroxy-labda-8(17),13E-dien-3-one 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以90%的产率得到ent-3α,15-dihydroxy-labda-8(17),13(E)-diene
  参考文献：
  名称：

  Three New Labdane-Type Diterpenes from Wood, Excoecaria agallocha.

  摘要：

  From the wood of Excoecaria agallocha LINN., three new labdane-type diterpenes, ent-11α-hydroxy-3-oxo-13-epi-manoyl oxide (4), ent-16-hydroxy-3-oxo-13-epi-manoyl oxide (5) and ent-15-hydroxy-labda-8(17), 13E-diene-3-one (6) were isolated together with three known compounds, ent-3-oxo-13-epi-manoyl oxide (ribenone, 1), ent-3β-hydroxy-13-epi-manoyl oxide (ribenol, 2) and ent-13-epi-manoyl oxide (3), and their structures were determined.

  DOI：

  10.1248/cpb.44.229

文献信息

• Labdane-Type Diterpene Glycosides from Fruits of Rubus foliolosus.
  作者：Kazuhiro OHTANI、Chong-Ren YANG、Chikako MIYAJIMA、Jun ZHOU、Osamu TANAKA

  DOI：10.1248/cpb.39.2443

  日期：——

  From fruits of Rubus foliolosus (Rosaceae), a traditional medicine used in Yunnan, China, seven labdane-type diterpene glycosides were isolated. Of these glycosides, five were identified as goshonosides-F1-5 (1-5) which have been isolated from leaves of R. chingii. Structures of two new glycosides, goshonosides-F6 (6) and -F7 (8), were elucidated as α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside of 13(E)-ent-labda-8(17), 13-diene-3β, 15, 18-triol and 3β, 15-di-O-β-D-glucopyranoside of 13(E)-ent-labda-8(17), 13-diene-3β, 15-diol. Goshonosides-F6 (6) and -F7 (8) were also isolated from the leaves of R. chingii.