3,3-dimethoxy-11β-(3-methoxyphenyl)-19-nor-17α-pregn-9-en-20-yn-5α,17 diol | 717890-77-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,3-dimethoxy-11β-(3-methoxyphenyl)-19-nor-17α-pregn-9-en-20-yn-5α,17 diol
• 英文别名: (5R,8S,11R,13S,14S,17R)-17-ethynyl-3,3-dimethoxy-11-(3-methoxyphenyl)-13-methyl-2,4,6,7,8,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-5,17-diol
• CAS: 717890-77-2
• 化学式: C₂₉H₃₈O₅
• 分子量: 466.618
• InChiKey: ALHGIXOOGGFYHO-IINHIXHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC HETEROCYCLES AS FGFR INHIBITORS<br/>[FR] HÉTÉROCYCLES BICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE FGFR
  申请人：INCYTE CORP

  公开号：WO2016134320A1

  公开（公告）日：2016-08-25

  The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 and/or FGFR4 enzyme and are useful in the treatment of FGFR-associated diseases.

  本公开涉及双环杂环化合物及其药物组合物，这些化合物是FGFR3和/或FGFR4酶的抑制剂，可用于治疗与FGFR相关的疾病。
• NEW ENZYMATIC PROCESS FOR THE PREPARATION OF TESTOSTERONE AND ESTERS THEREOF
  申请人：F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A

  公开号：US20170029863A1

  公开（公告）日：2017-02-02

  The present invention relates to a new process for the preparation of testosterone by means of enzymatic hydrolysis of testosterone esters.

  本发明涉及一种通过酶解睾酮酯类物质制备睾酮的新工艺。
• BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
  申请人：Incyte Corporation

  公开号：US20160244449A1

  公开（公告）日：2016-08-25

  The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 and/or FGFR4 enzyme and are useful in the treatment of FGFR-associated diseases.

  本公开涉及双环杂环化合物及其制药组合物，该制药组合物是FGFR3和/或FGFR4酶的抑制剂，并且在FGFR相关疾病的治疗中有用。
• ENZYMATIC PROCESS FOR THE PREPARATION OF TESTOSTERONE AND ESTERS THEREOF
  申请人：F.I.S.- Fabbrica Italiana Sintetici S.p.A.

  公开号：EP3064589A1

  公开（公告）日：2016-09-07

  The present invention relates to a process for the preparation of Testosterone by means of enzymatic hydrolysis of Testosterone esters, wherein the enzyme is a lipase from Aspergillus oryzae or a lipase from Candida Antarctica A.

  本发明涉及一种通过酶水解睾酮酯制备睾酮的工艺，其中酶是一种来自黑曲霉或南极念珠菌 A 的脂肪酶。
• Bicyclic heterocycles as FGFR4 inhibitors
  申请人：Incyte Corporation

  公开号：US10251892B2

  公开（公告）日：2019-04-09

  The present disclosure relates to bicyclic heterocycles of Formula (I′), and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 and/or FGFR4 enzyme and are useful in the treatment of FGFR-associated diseases.

  本公开涉及式（I′）的双环杂环及其药物组合物，它们是 FGFR3 和/或 FGFR4 酶的抑制剂，可用于治疗 FGFR 相关疾病。