8-iodo-2-methyl-N,N-dipropylquinolin-4-amine | 620179-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-iodo-2-methyl-N,N-dipropylquinolin-4-amine
• CAS: 620179-10-4
• 化学式: C₁₆H₂₁IN₂
• 分子量: 368.261
• InChiKey: OIBZFFQGEOXMSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-二甲氧基苯硼酸 、 8-iodo-2-methyl-N,N-dipropylquinolin-4-amine 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 苯 为溶剂， 生成 [8-(2,4-Dimethoxy-phenyl)-2-methyl-quinolin-4-yl]-dipropyl-amine
  参考文献：
  名称：

  Synthesis and SAR of 8-Arylquinolines as potent corticotropin-Releasing factor1 (CRF1) receptor antagonists

  摘要：

  A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF1 receptor. This series of compounds displayed parallel SAR to other bicyclic systems such as pyrazolo[l,5-a]pyrimidines, with several compounds possessing low nanomolar binding affinity. In addition to the high potency, the basicity of this 4-aminoquinoline core may offer CRF1 antagonists with lower lipophilicity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00684-x
• 作为产物：
  描述：

  2-碘苯胺 在 对甲苯磺酸 、 三氯氧磷 作用下， 以 二苯醚 、 苯 为溶剂， 生成 8-iodo-2-methyl-N,N-dipropylquinolin-4-amine
  参考文献：
  名称：

  Synthesis and SAR of 8-Arylquinolines as potent corticotropin-Releasing factor1 (CRF1) receptor antagonists

  摘要：

  A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF1 receptor. This series of compounds displayed parallel SAR to other bicyclic systems such as pyrazolo[l,5-a]pyrimidines, with several compounds possessing low nanomolar binding affinity. In addition to the high potency, the basicity of this 4-aminoquinoline core may offer CRF1 antagonists with lower lipophilicity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00684-x