(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(2-aminophenoxy)tetrahydro-2H-pyran-3,4,5-triyltriacetate | 36874-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(2-aminophenoxy)tetrahydro-2H-pyran-3,4,5-triyltriacetate
• 英文别名: o-Aminophenyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosid；(2-amino-phenyl)-(tetra-O-acetyl-β-D-glucopyranoside)；(2-Amino-phenyl)-(tetra-O-acetyl-β-D-glucopyranosid)；I(2)-D-Glucopyranoside, 2-aminophenyl, 2,3,4,6-tetraacetate；[(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-(2-aminophenoxy)oxan-2-yl]methyl acetate
• CAS: 36874-79-0
• 化学式: C₂₀H₂₅NO₁₀
• 分子量: 439.419
• InChiKey: VBQJTLMFGLYFGD-OUUBHVDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  150
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(2-aminophenoxy)tetrahydro-2H-pyran-3,4,5-triyltriacetate 在 dimethyl sulfide borane 、 乙酸酐 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成 (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(2-(methylamino)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
  参考文献：
  名称：

  Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation

  摘要：

  报道了一种新的可渗透细胞的过硫化物和硫化氢供体，可以保护细胞免受氧化应激的影响。

  DOI：

  10.1039/d1cc07162a
• 作为产物：
  描述：

  乙酰溴葡糖 在 盐酸 、 silver(l) oxide 、 锌 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 48.0h， 生成 (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(2-aminophenoxy)tetrahydro-2H-pyran-3,4,5-triyltriacetate
  参考文献：
  名称：

  Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation

  摘要：

  报道了一种新的可渗透细胞的过硫化物和硫化氢供体，可以保护细胞免受氧化应激的影响。

  DOI：

  10.1039/d1cc07162a

文献信息

• AMINO- AND GUANIDINO-PHENYLGLUCOSIDES
  作者：H. GEORGE LATHAM、EVERETTE L. MAY、ERICH MOSETTIG

  DOI：10.1021/jo01150a028

  日期：1950.7
• [EN] COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF<br/>[FR] COMPOSÉS COMPRENANT UN LIEUR CLIVABLE ET LEURS UTILISATIONS
  申请人：INTOCELL INC

  公开号：WO2020141460A2

  公开（公告）日：2020-07-09

  Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a -S(=0)(=N-)- functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.