6-hydroxy-decahydro-[2]naphthoic acid | 36126-74-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-hydroxy-decahydro-[2]naphthoic acid
• 英文别名: 6-Hydroxy-decahydro-[2]naphthoesaeure；6-Hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene-2-carboxylic acid
• CAS: 36126-74-6
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: LSRDTCGQIYGLLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-羟基-6-萘甲酸 在 盐酸 、 sodium ethanolate 、 镍 作用下， 200.0 ℃ 、16.47 MPa 条件下， 生成 6-hydroxy-decahydro-[2]naphthoic acid
  参考文献：
  名称：

  The Hydrogenation of Some Substituted β-Naphthols¹

  摘要：

  DOI：

  10.1021/ja01161a066

文献信息

• [EN] NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)<br/>[FR] DERIVES DE NAPHTALENE QUI INHIBENT LA CYTOKINE OU L'ACTIVITE BIOLOGIQUE DU FACTEUR INHIBITEUR DE MIGRATION DU MACROPHAGE
  申请人：CORTICAL PTY LTD

  公开号：WO2003104178A1

  公开（公告）日：2003-12-18

  Where Y, R1-R8 and R101-R108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy.

  在规范中定义的Y、R1-R8和R101-R108，化合物的化学式(II)和抑制巨噬细胞迁移抑制因子(MIF)细胞因子或生物活性的方法包括将MIF与化学式(I)的化合物接触。该发明还涉及治疗MIF细胞因子或生物活性涉及的疾病或病况的方法，包括给予化学式(I)的化合物，单独或作为联合治疗的一部分。
• COATING COMPOSITIONS SUITABLE FOR USE WITH AN OVERCOATED PHOTORESIST
  申请人：Amara John P.

  公开号：US20110003250A1

  公开（公告）日：2011-01-06

  In one aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise that comprise a diene/dienophile reaction product. In another aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise a component comprising a hydroxyl-naphthoic group, such as a 6-hydroxy-2-naphthoic group Preferred compositions of the invention are useful to reduce reflection of exposing radiation from a substrate back into an overcoated photoresist layer and/or function as a planarizing, conformal or via-fill layer.

  在一个方面，提供了有机涂层组合物，特别是抗反射涂层组合物，其包括二烯/二烯亲双反应产物。在另一个方面，提供了有机涂层组合物，特别是抗反射涂层组合物，其包括一个含有羟基-萘甲基团的组分，例如6-羟基-2-萘甲基团。本发明的优选组合物可用于减少曝光辐射从基板反射回覆盖的光刻胶层，并/或作为平坦化、整平或填孔层。
• Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif)
  申请人：Morand Francis Eric

  公开号：US20060106102A1

  公开（公告）日：2006-05-18

  Where Y, R 1 -R 8 and R 101 -R 108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (1), either alone or as part of a combination therapy.

  本发明提供了式(II)化合物及抑制巨噬细胞迁移抑制因子(MIF)细胞因子或生物活性的方法，其中Y，R1-R8和R101-R108如规范中定义。该方法包括将MIF与式(I)化合物接触。本发明还涉及治疗MIF细胞因子或生物活性所涉及的疾病或病症的方法，包括单独或作为联合治疗的一部分给予式(1)化合物。
• A polyester and an article made of the same
  申请人：SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0344099A2

  公开（公告）日：1989-11-29

  A polyester is provided that comprises as main monomer components thereof a dicarboxylic acid and a diol, including a p-quaterphenyl derivative of specific formula. The use of appropriate kinds of dicarboxylic acid for the polyester makes it possible to obtain a thermoplastic elastomer or an engineering plastic material (i.e., liquid-crystal polymer).

  本发明提供了一种聚酯，其主要单体成分包括二羧酸和二元醇，包括特定式的对四联苯衍生物。在聚酯中使用适当种类的二羧酸，可以获得热塑性弹性体或工程塑料材料（即液晶聚合物）。
• Coating compositions suitable for use with an overcoated photoresist
  申请人：Rohm and Haas Electronic Materials, LLC

  公开号：EP2261738A2

  公开（公告）日：2010-12-15

  In one aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise that comprise a diene/dienophile reaction product. In another aspect, organic coating compositions, particularly antireflective coating compositions, are provided that comprise a component comprising a hydroxyl-naphthoic group, such as a 6-hydroxy-2-naphthoic group Preferred compositions of the invention are useful to reduce reflection of exposing radiation from a substrate back into an overcoated photoresist layer and/or function as a planarizing, conformal or via-fill layer.

  一方面，有机涂层组合物，尤其是减反射涂层组合物，包含二烯/亲二烯反应产物。在另一方面，提供的有机涂层组合物，尤其是抗反射涂层组合物，包含一个由羟基-萘基（如 6-羟基-2-萘基）组成的组分。 本发明的优选组合物有助于减少曝光辐射从基底反射回涂层光刻胶层和/或用作平面化、保形或通孔填充层。