7-(3,4-dimethoxy-phenyl)-furo[3,2-g]chromen-5-one | 95277-26-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-(3,4-dimethoxy-phenyl)-furo[3,2-g]chromen-5-one
• 英文别名: 3',4'-Dimethoxy-furano(3',2',6,7)-flavon；7-(3,4-Dimethoxyphenyl)-5H-furo[3,2-g][1]benzopyran-5-one；7-(3,4-dimethoxyphenyl)furo[3,2-g]chromen-5-one
• CAS: 95277-26-2
• 化学式: C₁₉H₁₄O₅
• 分子量: 322.317
• InChiKey: BRZNASDQWSEEMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4-二羟基苯乙酮 在 A 15 吡啶 、 硫酸 、 potassium tert-butylate 、 potassium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 6.17h， 生成 7-(3,4-dimethoxy-phenyl)-furo[3,2-g]chromen-5-one
  参考文献：
  名称：

  Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

  摘要：

  Protein tyrosine phosphatase 113 (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.053

文献信息

• Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors
  作者：Manish Dixit、Brajendra K. Tripathi、Akhilesh K. Tamrakar、Arvind K. Srivastava、Brijesh Kumar、Atul Goel

  DOI：10.1016/j.bmc.2006.10.053

  日期：2007.1

  Protein tyrosine phosphatase 113 (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.