7-phenyl-furo[3,2-g]chromen-5-one | 4439-70-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-phenyl-furo[3,2-g]chromen-5-one
• 英文别名: 7-Phenyl-furo[3,2-g]chromen-5-on；Furano<2'.3':6.7>flavon；7-Phenyl-furo[3,2-g]chromen-5-one；7-phenylfuro[3,2-g]chromen-5-one
• CAS: 4439-70-7
• 化学式: C₁₇H₁₀O₃
• 分子量: 262.265
• InChiKey: RIFWZGCPXPFPAY-UHFFFAOYSA-N

物化性质

• 熔点：
  168-169 °C(Solv: ethanol (64-17-5))
• 沸点：
  424.9±45.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二羟基苯乙酮 在 A 15 吡啶 、 硫酸 、 potassium tert-butylate 、 potassium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 6.17h， 生成 7-phenyl-furo[3,2-g]chromen-5-one
  参考文献：
  名称：

  Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

  摘要：

  Protein tyrosine phosphatase 113 (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.053

文献信息

• Pavanaram; Row, Current Science, 1955, vol. 24, p. 301
  作者：Pavanaram、Row

  DOI：——

  日期：——
• Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors
  作者：Manish Dixit、Brajendra K. Tripathi、Akhilesh K. Tamrakar、Arvind K. Srivastava、Brijesh Kumar、Atul Goel

  DOI：10.1016/j.bmc.2006.10.053

  日期：2007.1

  Protein tyrosine phosphatase 113 (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in muscle and liver as well as resistance to obesity. A series of hydroxy benzofuran methyl ketones and their naturally mimicking dimers and linear and angular furanochalcones and flavones have been evaluated as PTP-1B inhibitors. Screened compounds displayed good inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.