磺基-N-琥珀酰亚胺基4-马来酰亚胺丁酸钠盐 | 185332-92-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 磺基-N-琥珀酰亚胺基4-马来酰亚胺丁酸钠盐
• 英文名称: Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt
• 英文别名: sodium;1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate
• CAS: 185332-92-7
• 化学式: C12H11N2NaO9S
• 分子量: 382.28
• InChiKey: ULARYIUTHAWJMU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.17
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  167
• 氢给体数：
  0
• 氢受体数：
  9

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

文献信息

• METHOD OF ACQUIRING INFORMATION REGARDING BASE SEQUENCE AND INFORMATION READING DEVICE FOR THE SAME
  申请人：Nomoto Tsuyoshi

  公开号：US20090233280A1

  公开（公告）日：2009-09-17

  Information regarding a base sequence of a target nucleic acid is acquired by preparing a sample comprising the target nucleic acid hybridized with a primer or a sample comprising the target nucleic acid containing a promoter sequence, a polymerase, a nucleotide derivative having an electrochemically convertible moiety; allowing the three components to coexist in a solvent; and detecting whether the nucleotide derivative is introduced into the primer or a transcription product of the target nucleic acid or not using an electrochemical reaction.

  通过准备一个样品，其中包括与引物杂交的目标核酸或包含启动子序列的目标核酸样品，加入聚合酶、具有电化学可转化基团的核苷酸衍生物的溶剂，使三种组分共存；并使用电化学反应检测核苷酸衍生物是否被引入到引物或目标核酸的转录产物中。从而获得有关目标核酸碱基序列的信息。
• COMPOSITIONS FOR PREVENTING URINARY CALCULUS
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：EP1323433A1

  公开（公告）日：2003-07-02

  Provided is a composition for preventing urinary calculi caused by metal ions liberated from a compound containing a lanthanoid metal or another heavy metal in image diagnosis or therapy using that compound. The composition is a urinary calculus preventing composition containing a multidentate ligand capable of forming a complex with lanthanoid metal ions or other heavy metal ions, or an alkaline earth metal complex of that ligand. The multidentate ligand can be a bifunctional ligand having a polyaminopolycarboxylic acid, polyaminopolyphosphonic acid or the like as its site for forming a complex with a metal and chemically bonded to a physiologically acceptable oligosaccharide or the like, or can also be a polyaminopolycarboxylic or polyaminopolyphosphonic acid per se. Preferably, the polyaminopolycarboxylic acid is EDTA, DTPA, DOTA or TETA, or a derivative thereof.

  本发明提供了一种组合物，用于在使用含有镧系金属或其他重金属的化合物进行图像诊断或治疗时，防止从该化合物中释放出的金属离子引起尿结石。该组合物是一种防止尿结石的组合物，含有能够与镧系金属离子或其他重金属离子形成络合物的多叉配体，或该配体的碱土金属络合物。多叉配体可以是以多氨基多羧酸、多氨基多膦酸等作为与金属形成络合物的位点，并与生理上可接受的寡糖等化学键合的双功能配体，也可以是多氨基多羧酸或多氨基多膦酸本身。聚氨基多羧酸最好是 EDTA、DTPA、DOTA 或 TETA 或其衍生物。
• Methods and apparatus for detecting compounds in liquids
  申请人：Undercover Colors, Inc.

  公开号：US10024873B2

  公开（公告）日：2018-07-17

  Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

  本文描述的是用于检测液体中的滥用物质或其他分析物的仪器和方法。例如，本文所述仪器和方法可用于实时检测分析物，如滥用物质。这些方法包括提供一个检测区，该检测区包括一个色谱膜，该色谱膜能够接收液体并允许液体迁移，该色谱膜包括抗分析物抗体-颗粒共轭物、检测线上的分析物-共轭蛋白；将仪器的至少第一个位置暴露在液体中；以及确定分析物-共轭蛋白与液体之间是否发生相互作用，以检测分析物的存在。色谱膜可进一步包括控制线上的抗物种抗体。公开了特定的缓冲液，这些缓冲液可用于仪器的制备，以克服与微型化相关的挑战和与暴露于饮料相关的挑战。
• Compositions for preventing urinary calculus
  申请人：——

  公开号：US20030186845A1

  公开（公告）日：2003-10-02

  Provided is a composition for preventing urinary calculi caused by metal ions liberated from a compound containing a lanthanoid metal or another heavy metal in image diagnosis or therapy using that compound. The composition is a urinary calculus preventing composition containing a multidentate ligand capable of forming a complex with lanthanoid metal ions or other heavy metal ions, or an alkaline earth metal complex of that ligand. The multidentate ligand can be a bifunctional ligand having a polyaminopolycarboxylic acid, polyaminopolyphosphonic acid or the like as its site for forming a complex with a metal and chemically bonded to a physiologically acceptable oligosaccharide or the like, or can also be a polyaminopolycarboxylic or polyaminopolyphosphonic acid per se. Preferably, the polyaminopolycarboxylic acid is EDTA, DTPA, DOTA or TETA, or a derivative thereof.

  本发明提供了一种组合物，用于在使用含有镧系金属或其他重金属的化合物进行图像诊断或治疗时，防止从该化合物中释放出的金属离子引起尿结石。该组合物是一种防止尿结石的组合物，含有能够与镧系金属离子或其他重金属离子形成络合物的多叉配体，或该配体的碱土金属络合物。多叉配体可以是以多氨基多羧酸、多氨基多膦酸等作为与金属形成络合物的位点，并与生理上可接受的寡糖等化学键合的双功能配体，也可以是多氨基多羧酸或多氨基多膦酸本身。聚氨基多羧酸最好是 EDTA、DTPA、DOTA 或 TETA 或其衍生物。
• METHODS AND APPARATUS FOR DETECTING COMPOUNDS IN LIQUIDS
  申请人：Undercover Colors, Inc.

  公开号：US20170242045A1

  公开（公告）日：2017-08-24

  Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.