Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives
摘要:
A series of new, diene-modified nodulisporic acid analogues (2) bearing diverse functionality at the 3"- and 4"-sites was efficiently prepared from the 3"-aldehyde 3. Biological evaluation of these synthetic nodulisporic acid analogues for systemic flea efficacy identified potent compounds and further clarified the structural requirements for ectoparasite activity. (C) 2002 Elsevier Science Ltd. All rights reserved.
Side-chain homologation of nodulisporic acid: synthesis of potent new dienyl derivatives
摘要:
A series of new, diene-modified nodulisporic acid analogues (2) bearing diverse functionality at the 3"- and 4"-sites was efficiently prepared from the 3"-aldehyde 3. Biological evaluation of these synthetic nodulisporic acid analogues for systemic flea efficacy identified potent compounds and further clarified the structural requirements for ectoparasite activity. (C) 2002 Elsevier Science Ltd. All rights reserved.